Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe
Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a nov...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/14/4340 |
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| author | Mikhail Panfilov Darya Chernova Irina Khalfina Alexander Moskalensky Aleksey Vorob’ev |
| author_facet | Mikhail Panfilov Darya Chernova Irina Khalfina Alexander Moskalensky Aleksey Vorob’ev |
| author_sort | Mikhail Panfilov |
| collection | DOAJ |
| description | Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10<i>H</i>)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10<i>H</i>)acridone reacts with NO in aqueous media in the presence of O<sub>2</sub>, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells. |
| first_indexed | 2024-03-10T09:30:14Z |
| format | Article |
| id | doaj.art-2384238a20ef46efb655a99a77610c47 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:30:14Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2384238a20ef46efb655a99a77610c472023-11-22T04:32:19ZengMDPI AGMolecules1420-30492021-07-012614434010.3390/molecules26144340Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent ProbeMikhail Panfilov0Darya Chernova1Irina Khalfina2Alexander Moskalensky3Aleksey Vorob’ev4Novosibirsk Institute of Organic Chemistry, 9 Lavrentiev Avenue, 630090 Novosibirsk, RussiaDepartment of Physics, Novosibirsk State University, 630090 Novosibirsk, RussiaNovosibirsk Institute of Organic Chemistry, 9 Lavrentiev Avenue, 630090 Novosibirsk, RussiaDepartment of Physics, Novosibirsk State University, 630090 Novosibirsk, RussiaNovosibirsk Institute of Organic Chemistry, 9 Lavrentiev Avenue, 630090 Novosibirsk, RussiaNitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and biochemical studies. Here, we report the design of a novel small-molecule fluorescent probe based on 9(10<i>H</i>)acridone moiety for nitric oxide sensing. 7,8-Diamino-4-carboxy-10-methyl-9(10<i>H</i>)acridone reacts with NO in aqueous media in the presence of O<sub>2</sub>, yielding a corresponding triazole derivative with fivefold increased fluorescence intensity. The probe was shown to be capable of nitric oxide sensing in living Jurkat cells.https://www.mdpi.com/1420-3049/26/14/4340nitric oxide probes9(10<i>H</i>)acridonefluorescent probes |
| spellingShingle | Mikhail Panfilov Darya Chernova Irina Khalfina Alexander Moskalensky Aleksey Vorob’ev Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe Molecules nitric oxide probes 9(10<i>H</i>)acridone fluorescent probes |
| title | Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe |
| title_full | Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe |
| title_fullStr | Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe |
| title_full_unstemmed | Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe |
| title_short | Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe |
| title_sort | design and synthesis of new acridone based nitric oxide fluorescent probe |
| topic | nitric oxide probes 9(10<i>H</i>)acridone fluorescent probes |
| url | https://www.mdpi.com/1420-3049/26/14/4340 |
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