Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin
Oligodendrocytes (OLs) and Schwann cells (SCs) have traditionally been thought of as the exclusive myelinating glial cells of the central and peripheral nervous systems (CNS and PNS), respectively, for a little over a century. However, recent studies demonstrate the existence of a novel, centrally-d...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00333/full |
| _version_ | 1818499784668872704 |
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| author | Laura Fontenas Sarah Kucenas |
| author_facet | Laura Fontenas Sarah Kucenas |
| author_sort | Laura Fontenas |
| collection | DOAJ |
| description | Oligodendrocytes (OLs) and Schwann cells (SCs) have traditionally been thought of as the exclusive myelinating glial cells of the central and peripheral nervous systems (CNS and PNS), respectively, for a little over a century. However, recent studies demonstrate the existence of a novel, centrally-derived peripheral glial population called motor exit point (MEP) glia, which myelinate spinal motor root axons in the periphery. Until recently, the boundaries that exist between the CNS and PNS, and the cells permitted to cross them, were mostly described based on fixed histological collections and static lineage tracing. Recent work in zebrafish using in vivo, time-lapse imaging has shed light on glial cell interactions at the MEP transition zone and reveals a more complex picture of myelination both centrally and peripherally. |
| first_indexed | 2024-12-10T20:34:19Z |
| format | Article |
| id | doaj.art-2385187ba0d84ab2865353fdb7fae498 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T20:34:19Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-2385187ba0d84ab2865353fdb7fae4982022-12-22T01:34:34ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-10-011210.3389/fncel.2018.00333407086Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS MyelinLaura FontenasSarah KucenasOligodendrocytes (OLs) and Schwann cells (SCs) have traditionally been thought of as the exclusive myelinating glial cells of the central and peripheral nervous systems (CNS and PNS), respectively, for a little over a century. However, recent studies demonstrate the existence of a novel, centrally-derived peripheral glial population called motor exit point (MEP) glia, which myelinate spinal motor root axons in the periphery. Until recently, the boundaries that exist between the CNS and PNS, and the cells permitted to cross them, were mostly described based on fixed histological collections and static lineage tracing. Recent work in zebrafish using in vivo, time-lapse imaging has shed light on glial cell interactions at the MEP transition zone and reveals a more complex picture of myelination both centrally and peripherally.https://www.frontiersin.org/article/10.3389/fncel.2018.00333/fullmyelinoligodendrocyteschwann cellmotor exit point gliazebrafishboundary cap cell |
| spellingShingle | Laura Fontenas Sarah Kucenas Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin Frontiers in Cellular Neuroscience myelin oligodendrocyte schwann cell motor exit point glia zebrafish boundary cap cell |
| title | Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin |
| title_full | Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin |
| title_fullStr | Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin |
| title_full_unstemmed | Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin |
| title_short | Motor Exit Point (MEP) Glia: Novel Myelinating Glia That Bridge CNS and PNS Myelin |
| title_sort | motor exit point mep glia novel myelinating glia that bridge cns and pns myelin |
| topic | myelin oligodendrocyte schwann cell motor exit point glia zebrafish boundary cap cell |
| url | https://www.frontiersin.org/article/10.3389/fncel.2018.00333/full |
| work_keys_str_mv | AT laurafontenas motorexitpointmepglianovelmyelinatinggliathatbridgecnsandpnsmyelin AT sarahkucenas motorexitpointmepglianovelmyelinatinggliathatbridgecnsandpnsmyelin |