Pt(II)-Thiocarbohydrazone Complex as Cytotoxic Agent and Apoptosis Inducer in Caov-3 and HT-29 Cells through the P53 and Caspase-8 Pathways

Pt(II)-Thiocarbohydrazone Complex as Cytotoxic Agent and Apoptosis Inducer in Caov-3 and HT-29 Cells through the P53 and Caspase-8 Pathways

In this study, a platinum(II) complex ([Pt(H<sub>2</sub>L)(PPh<sub>3</sub>)] complex) containing a thiocarbohydrazone as the ligand was tested as an anti-proliferative agent against ovarian adenocarcinoma (Caov-3) and human colorectal adenocarcinoma (HT-29) through MTT assays...

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Bibliographic Details
Main Authors: Abeer A. Ibrahim, Mohanad M. Kareem, Taghreed H. Al-Noor, Tahani Al-Muhimeed, Abeer A. AlObaid, Salim Albukhaty, Ghassan M. Sulaiman, Majid Jabir, Zainab J. Taqi, Usama I. Sahib
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
Pt(II) complex
anticancer activity
apoptosis
DNA fragmentation
p53
caspase-8
Online Access:https://www.mdpi.com/1424-8247/14/6/509

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