Case report: Personalized computational model guided ablation for left atrial flutter
Atypical atrial flutter is seen post-ablation in patients, and it can be challenging to map. These flutters are typically set up around areas of scar in the left atrium. MRI can reliably identify left atrial scar. We propose a personalized computational model using patient specific scar information,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.893752/full |
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| author | Matthias Lange Eugene Kwan Eugene Kwan Derek J. Dosdall Derek J. Dosdall Derek J. Dosdall Rob S. MacLeod Rob S. MacLeod Rob S. MacLeod T. Jared Bunch Ravi Ranjan Ravi Ranjan Ravi Ranjan |
| author_facet | Matthias Lange Eugene Kwan Eugene Kwan Derek J. Dosdall Derek J. Dosdall Derek J. Dosdall Rob S. MacLeod Rob S. MacLeod Rob S. MacLeod T. Jared Bunch Ravi Ranjan Ravi Ranjan Ravi Ranjan |
| author_sort | Matthias Lange |
| collection | DOAJ |
| description | Atypical atrial flutter is seen post-ablation in patients, and it can be challenging to map. These flutters are typically set up around areas of scar in the left atrium. MRI can reliably identify left atrial scar. We propose a personalized computational model using patient specific scar information, to generate a monodomain model. In the model conductivities are adjusted for different tissue regions and flutter was induced with a premature pacing protocol. The model was tested prospectively in patients undergoing atypical flutter ablation. The simulation-predicted flutters were visualized and presented to clinicians. Validation of the computational model was motivated by recording from electroanatomical mapping. These personalized models successfully predicted clinically observed atypical flutter circuits and at times even better than invasive maps leading to flutter termination at isthmus sites predicted by the model. |
| first_indexed | 2024-04-12T21:13:33Z |
| format | Article |
| id | doaj.art-23889fbaceee4f9a8a7fc5b27bcd2248 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T21:13:33Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-23889fbaceee4f9a8a7fc5b27bcd22482022-12-22T03:16:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.893752893752Case report: Personalized computational model guided ablation for left atrial flutterMatthias Lange0Eugene Kwan1Eugene Kwan2Derek J. Dosdall3Derek J. Dosdall4Derek J. Dosdall5Rob S. MacLeod6Rob S. MacLeod7Rob S. MacLeod8T. Jared Bunch9Ravi Ranjan10Ravi Ranjan11Ravi Ranjan12Nora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT, United StatesNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT, United StatesBiomedical Engineering, The University of Utah, Salt Lake City, UT, United StatesNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT, United StatesBiomedical Engineering, The University of Utah, Salt Lake City, UT, United StatesDepartment of Surgery, Division of Cardiothoracic Surgery, University of Utah School of Medicine, Salt Lake City, UT, United StatesNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT, United StatesBiomedical Engineering, The University of Utah, Salt Lake City, UT, United StatesScientific Computing and Imaging Institute, The University of Utah, Salt Lake City, UT, United StatesDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, United StatesNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT, United StatesBiomedical Engineering, The University of Utah, Salt Lake City, UT, United StatesDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, UT, United StatesAtypical atrial flutter is seen post-ablation in patients, and it can be challenging to map. These flutters are typically set up around areas of scar in the left atrium. MRI can reliably identify left atrial scar. We propose a personalized computational model using patient specific scar information, to generate a monodomain model. In the model conductivities are adjusted for different tissue regions and flutter was induced with a premature pacing protocol. The model was tested prospectively in patients undergoing atypical flutter ablation. The simulation-predicted flutters were visualized and presented to clinicians. Validation of the computational model was motivated by recording from electroanatomical mapping. These personalized models successfully predicted clinically observed atypical flutter circuits and at times even better than invasive maps leading to flutter termination at isthmus sites predicted by the model.https://www.frontiersin.org/articles/10.3389/fcvm.2022.893752/fullatypical left atrial flutterpersonalized computational modelpredicting atrial flutterablationprospective study |
| spellingShingle | Matthias Lange Eugene Kwan Eugene Kwan Derek J. Dosdall Derek J. Dosdall Derek J. Dosdall Rob S. MacLeod Rob S. MacLeod Rob S. MacLeod T. Jared Bunch Ravi Ranjan Ravi Ranjan Ravi Ranjan Case report: Personalized computational model guided ablation for left atrial flutter Frontiers in Cardiovascular Medicine atypical left atrial flutter personalized computational model predicting atrial flutter ablation prospective study |
| title | Case report: Personalized computational model guided ablation for left atrial flutter |
| title_full | Case report: Personalized computational model guided ablation for left atrial flutter |
| title_fullStr | Case report: Personalized computational model guided ablation for left atrial flutter |
| title_full_unstemmed | Case report: Personalized computational model guided ablation for left atrial flutter |
| title_short | Case report: Personalized computational model guided ablation for left atrial flutter |
| title_sort | case report personalized computational model guided ablation for left atrial flutter |
| topic | atypical left atrial flutter personalized computational model predicting atrial flutter ablation prospective study |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.893752/full |
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