Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein

Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein

Summary The promiscuous activity of protein phosphatase one (PP1) is controlled in the cell by associated proteins termed regulatory or targeting subunits. Using biochemical and proteomic approaches we demonstrate that the autosomal recessive nonsyndromic hearing loss gene, taperin (C9orf75), encode...

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Bibliographic Details
Main Authors: Tony Ferrar, Delphine Chamousset, Veerle De Wever, Mhairi Nimick, Jens Andersen, Laura Trinkle-Mulcahy, Greg B. G. Moorhead
Format: Article
Language:English
Published: The Company of Biologists 2012-02-01
Series:Biology Open
Subjects:
Nonsyndromic deafness
Nucleus
Protein phosphatase one (PP1)
Protein phosphorylation
Phostensin
DNA damage
Online Access:http://bio.biologists.org/content/1/2/128

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