Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in Psoriasis

Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in Psoriasis

Mast cells (MCs) contribute to skin inflammation. In psoriasis, the activation of cutaneous neuroimmune networks commonly leads to itch. To dissect the unique contribution of MCs to the cutaneous neuroinflammatory response in psoriasis, we examined their density, distribution, relation to nerve fibr...

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Bibliographic Details
Main Authors: Peter W. West, Chiara Tontini, Haris Atmoko, Orsolya Kiss, Terence Garner, Rajia Bahri, Richard B. Warren, Christopher E. M. Griffiths, Adam Stevens, Silvia Bulfone-Paus
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
mast cells
cathepsin B
psoriasis
itch
Online Access:https://www.mdpi.com/2073-4409/12/17/2177

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