The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease
Objective Although gastrointestinal dysfunctions occur in the majority of patients with Parkinson’s disease (PD), they are often unrecognized because many patients remain relatively asymptomatic in the early stage. We investigated the frequency of gastrointestinal symptoms in patients with PD using...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2014-04-01
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| Series: | Journal of Movement Disorders |
| Subjects: | |
| Online Access: | http://e-jmd.org/upload/jmd-7-1-7-2.pdf |
| _version_ | 1797760883305218048 |
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| author | Hye-Young Sung Jeong-Wook Park Joong-Seok Kim |
| author_facet | Hye-Young Sung Jeong-Wook Park Joong-Seok Kim |
| author_sort | Hye-Young Sung |
| collection | DOAJ |
| description | Objective Although gastrointestinal dysfunctions occur in the majority of patients with Parkinson’s disease (PD), they are often unrecognized because many patients remain relatively asymptomatic in the early stage. We investigated the frequency of gastrointestinal symptoms in patients with PD using newly developed gastrointestinal symptom questionnaires. Methods Early PD patients with a symptom duration not exceeding 3 years were included in this study. All PD patients were evaluated using a questionnaire, which consisted of three relevant domains: oropharyngoesophageal (10 items); gastric (3 items); and intestinal-anorectal (7 items). The frequency of symptoms was calculated as a proportion with an item score ≥ 2. Results Of the 54 patients enrolled, 48 patients (88.9%) responded that bowel symptoms developed before the onset of Parkinsonian motor symptoms, and four patients reported that the onset of two types of symptoms (i.e., bowel and neurological) occurred approximately simultaneously, with only months between them. The frequencies of gastrointestinal symptoms are as follows: speech disturbance (40.7%), drooling (24.1%), sense of getting stuck (31.5%), choking (27.8%), globus pharyngis (16.7%), repetitive deglutition (29.6%), pain during swallowing (5.6%), food regurgitation (3.7%), acid reflux (7.4%), nausea/vomiting (11.1%), early satiety (16.7%), postprandial fullness (14.8%), epigastric soreness (9.3%), abdominal pain (3.7%), constipation (46.3%), excessive strain during defecation (33.3%), fecal incontinence (7.4%), tenesmus (20.4%), loose stool or diarrhea (3.7%), and difficulty in relaxing anal sphincter (11.1%). Two patients were scored at zero. Conclusions Our findings confirm that gastrointestinal dysfunction occurs in early PD in relatively high frequency. |
| first_indexed | 2024-03-12T19:04:58Z |
| format | Article |
| id | doaj.art-238c809e61e044c686f37069761ecd6c |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T19:04:58Z |
| publishDate | 2014-04-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-238c809e61e044c686f37069761ecd6c2023-08-02T06:17:00ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392014-04-017171210.14802/jmd.14002107The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s DiseaseHye-Young SungJeong-Wook ParkJoong-Seok KimObjective Although gastrointestinal dysfunctions occur in the majority of patients with Parkinson’s disease (PD), they are often unrecognized because many patients remain relatively asymptomatic in the early stage. We investigated the frequency of gastrointestinal symptoms in patients with PD using newly developed gastrointestinal symptom questionnaires. Methods Early PD patients with a symptom duration not exceeding 3 years were included in this study. All PD patients were evaluated using a questionnaire, which consisted of three relevant domains: oropharyngoesophageal (10 items); gastric (3 items); and intestinal-anorectal (7 items). The frequency of symptoms was calculated as a proportion with an item score ≥ 2. Results Of the 54 patients enrolled, 48 patients (88.9%) responded that bowel symptoms developed before the onset of Parkinsonian motor symptoms, and four patients reported that the onset of two types of symptoms (i.e., bowel and neurological) occurred approximately simultaneously, with only months between them. The frequencies of gastrointestinal symptoms are as follows: speech disturbance (40.7%), drooling (24.1%), sense of getting stuck (31.5%), choking (27.8%), globus pharyngis (16.7%), repetitive deglutition (29.6%), pain during swallowing (5.6%), food regurgitation (3.7%), acid reflux (7.4%), nausea/vomiting (11.1%), early satiety (16.7%), postprandial fullness (14.8%), epigastric soreness (9.3%), abdominal pain (3.7%), constipation (46.3%), excessive strain during defecation (33.3%), fecal incontinence (7.4%), tenesmus (20.4%), loose stool or diarrhea (3.7%), and difficulty in relaxing anal sphincter (11.1%). Two patients were scored at zero. Conclusions Our findings confirm that gastrointestinal dysfunction occurs in early PD in relatively high frequency.http://e-jmd.org/upload/jmd-7-1-7-2.pdfParkinson’s diseaseGastrointestinal symptomsFrequencySeverity |
| spellingShingle | Hye-Young Sung Jeong-Wook Park Joong-Seok Kim The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease Journal of Movement Disorders Parkinson’s disease Gastrointestinal symptoms Frequency Severity |
| title | The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease |
| title_full | The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease |
| title_fullStr | The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease |
| title_full_unstemmed | The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease |
| title_short | The Frequency and Severity of Gastrointestinal Symptoms in Patients with Early Parkinson’s Disease |
| title_sort | frequency and severity of gastrointestinal symptoms in patients with early parkinson s disease |
| topic | Parkinson’s disease Gastrointestinal symptoms Frequency Severity |
| url | http://e-jmd.org/upload/jmd-7-1-7-2.pdf |
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