Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salina
The self-aggregation of pheophytin, a possible photosensitizer for Photodynamic Therapy, is solved by formulation in polymeric surfactant as P-123. The photosensitizer incorporation was found to be time dependent, exhibiting two steps: a partition at the micellar interface followed by an incorporati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2013-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100018&lng=en&tlng=en |
| _version_ | 1818922570111516672 |
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| author | Adriana Passarella Gerola Bianca Martins Estevão Wilker Caetano Noboru Hioka André Luiz Tessaro |
| author_facet | Adriana Passarella Gerola Bianca Martins Estevão Wilker Caetano Noboru Hioka André Luiz Tessaro |
| author_sort | Adriana Passarella Gerola |
| collection | DOAJ |
| description | The self-aggregation of pheophytin, a possible photosensitizer for Photodynamic Therapy, is solved by formulation in polymeric surfactant as P-123. The photosensitizer incorporation was found to be time dependent, exhibiting two steps: a partition at the micellar interface followed by an incorporation into the micelle core. The photodynamic efficiency of the formulation was tested by the bioassays against Artemia salina. In order to evaluate how the experimental parameters: pheophytin concentration, P-123 percentage and illumination time influenced the death of artemia, the factorial design 2³ was chosen. The illumination time was found to be the main factor contributing to the mortality of artemia. |
| first_indexed | 2024-12-20T01:55:38Z |
| format | Article |
| id | doaj.art-238c97ec11104445a9087208f29e5753 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-20T01:55:38Z |
| publishDate | 2013-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-238c97ec11104445a9087208f29e57532022-12-21T19:57:30ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642013-01-013619710110.1590/S0100-40422013000100018S0100-40422013000100018Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salinaAdriana Passarella Gerola0Bianca Martins Estevão1Wilker Caetano2Noboru Hioka3André Luiz Tessaro4Universidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáUniversidade Estadual de MaringáThe self-aggregation of pheophytin, a possible photosensitizer for Photodynamic Therapy, is solved by formulation in polymeric surfactant as P-123. The photosensitizer incorporation was found to be time dependent, exhibiting two steps: a partition at the micellar interface followed by an incorporation into the micelle core. The photodynamic efficiency of the formulation was tested by the bioassays against Artemia salina. In order to evaluate how the experimental parameters: pheophytin concentration, P-123 percentage and illumination time influenced the death of artemia, the factorial design 2³ was chosen. The illumination time was found to be the main factor contributing to the mortality of artemia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100018&lng=en&tlng=enphotodynamic therapypheophytinpolymeric surfactant |
| spellingShingle | Adriana Passarella Gerola Bianca Martins Estevão Wilker Caetano Noboru Hioka André Luiz Tessaro Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salina Química Nova photodynamic therapy pheophytin polymeric surfactant |
| title | Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salina |
| title_full | Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salina |
| title_fullStr | Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salina |
| title_full_unstemmed | Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salina |
| title_short | Estudos quimiométricos da pheo formulada em pluronics®: ação fotodinâmica Sobre Artemia salina |
| title_sort | estudos quimiometricos da pheo formulada em pluronics r acao fotodinamica sobre artemia salina |
| topic | photodynamic therapy pheophytin polymeric surfactant |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000100018&lng=en&tlng=en |
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