Corneal Langerhans cells in children with celiac disease
Abstract Celiac disease (CeD) is a common small bowel enteropathy characterized by an altered adaptive immune system and increased mucosal antigen presenting cells. This study aims to establish if quantification of corneal Langerhans cells (LCs) using corneal confocal microscopy (CCM) could act as a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22376-w |
| _version_ | 1811233633860583424 |
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| author | Hoda Gad Ibrahim Mohammed Saras Saraswathi Bara Al-Jarrah Maryam Ferdousi Ioannis N. Petropoulos Georgios Ponirakis Adnan Khan Parul Singh Souhaila Al Khodor Mamoun Elawad Wesam Almasri Hatim Abdelrahman Khalid Hussain Mohamed A. Hendaus Fatma Al-Mudahka Khaled Abouhazima Anthony K. Akobeng Rayaz A. Malik |
| author_facet | Hoda Gad Ibrahim Mohammed Saras Saraswathi Bara Al-Jarrah Maryam Ferdousi Ioannis N. Petropoulos Georgios Ponirakis Adnan Khan Parul Singh Souhaila Al Khodor Mamoun Elawad Wesam Almasri Hatim Abdelrahman Khalid Hussain Mohamed A. Hendaus Fatma Al-Mudahka Khaled Abouhazima Anthony K. Akobeng Rayaz A. Malik |
| author_sort | Hoda Gad |
| collection | DOAJ |
| description | Abstract Celiac disease (CeD) is a common small bowel enteropathy characterized by an altered adaptive immune system and increased mucosal antigen presenting cells. This study aims to establish if quantification of corneal Langerhans cells (LCs) using corneal confocal microscopy (CCM) could act as a surrogate marker for antigen presenting cell status and hence disease activity in children with CeD. Twenty children with stable CeD and 20 age-matched controls underwent CCM and quantification of central corneal total, mature and immature LC density. There was no difference in age (11.78 ± 1.7 vs. 12.83 ± 1.91; P = 0.077) or height (1.38 ± 0.14 vs. 1.44 ± 0.13; P = 0.125). BMI (18.81 ± 3.90 vs. 22.26 ± 5.47; P = 0.031) and 25 OHD levels (43.50 ± 13.36 vs. 59.77 ± 22.45; P = 0.014) were significantly lower in children with CeD compared to controls. The total (33.33(16.67–59.37) vs. 51.56(30.21–85.42); P = 0.343), immature (33.33(16.67–52.08) vs. 44.79(29.17–82.29); P = 0.752) and mature (1.56(0–5) vs. 1.56(1.04–8.33); P = 0.752) LC density did not differ between the CeD and control groups. However, immature (r = 0.535, P = 0.015), mature (r = 0.464, P = 0.039), and total (r = 0.548, P = 0.012) LC density correlated with age. Immature (r = 0.602, P = 0.038) and total (r = 0.637, P = 0.026) LC density also correlated with tissue transglutaminase antibody (Anti-TtG) levels assessed in 12/20 subjects with CeD. There was no difference in corneal LC density between children with CeD and controls. However, the correlation between corneal LC density and anti-TtG levels suggests a relationship with disease activity in CeD and requires further study. |
| first_indexed | 2024-04-12T11:22:59Z |
| format | Article |
| id | doaj.art-238d19a964544ab1bcb22cfbf7bd06f1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T11:22:59Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-238d19a964544ab1bcb22cfbf7bd06f12022-12-22T03:35:18ZengNature PortfolioScientific Reports2045-23222022-10-011211510.1038/s41598-022-22376-wCorneal Langerhans cells in children with celiac diseaseHoda Gad0Ibrahim Mohammed1Saras Saraswathi2Bara Al-Jarrah3Maryam Ferdousi4Ioannis N. Petropoulos5Georgios Ponirakis6Adnan Khan7Parul Singh8Souhaila Al Khodor9Mamoun Elawad10Wesam Almasri11Hatim Abdelrahman12Khalid Hussain13Mohamed A. Hendaus14Fatma Al-Mudahka15Khaled Abouhazima16Anthony K. Akobeng17Rayaz A. Malik18Department Medicine, Weill Cornell Medicine-QatarDepartment of Internal Medicine, Albany Medical Center HospitalDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineInstitute of Cardiovascular Medicine, University of ManchesterDepartment Medicine, Weill Cornell Medicine-QatarDepartment Medicine, Weill Cornell Medicine-QatarFaculty of Health Sciences, Khyber Medical UniversityResearch Department, Sidra MedicineResearch Department, Sidra MedicineDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineDivision of Endocrinology, Sidra MedicineGeneral Pediatrics Department, Sidra MedicineDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineDivision of Gastroenterology, Hepatology, and Nutrition, Sidra MedicineDepartment Medicine, Weill Cornell Medicine-QatarAbstract Celiac disease (CeD) is a common small bowel enteropathy characterized by an altered adaptive immune system and increased mucosal antigen presenting cells. This study aims to establish if quantification of corneal Langerhans cells (LCs) using corneal confocal microscopy (CCM) could act as a surrogate marker for antigen presenting cell status and hence disease activity in children with CeD. Twenty children with stable CeD and 20 age-matched controls underwent CCM and quantification of central corneal total, mature and immature LC density. There was no difference in age (11.78 ± 1.7 vs. 12.83 ± 1.91; P = 0.077) or height (1.38 ± 0.14 vs. 1.44 ± 0.13; P = 0.125). BMI (18.81 ± 3.90 vs. 22.26 ± 5.47; P = 0.031) and 25 OHD levels (43.50 ± 13.36 vs. 59.77 ± 22.45; P = 0.014) were significantly lower in children with CeD compared to controls. The total (33.33(16.67–59.37) vs. 51.56(30.21–85.42); P = 0.343), immature (33.33(16.67–52.08) vs. 44.79(29.17–82.29); P = 0.752) and mature (1.56(0–5) vs. 1.56(1.04–8.33); P = 0.752) LC density did not differ between the CeD and control groups. However, immature (r = 0.535, P = 0.015), mature (r = 0.464, P = 0.039), and total (r = 0.548, P = 0.012) LC density correlated with age. Immature (r = 0.602, P = 0.038) and total (r = 0.637, P = 0.026) LC density also correlated with tissue transglutaminase antibody (Anti-TtG) levels assessed in 12/20 subjects with CeD. There was no difference in corneal LC density between children with CeD and controls. However, the correlation between corneal LC density and anti-TtG levels suggests a relationship with disease activity in CeD and requires further study.https://doi.org/10.1038/s41598-022-22376-w |
| spellingShingle | Hoda Gad Ibrahim Mohammed Saras Saraswathi Bara Al-Jarrah Maryam Ferdousi Ioannis N. Petropoulos Georgios Ponirakis Adnan Khan Parul Singh Souhaila Al Khodor Mamoun Elawad Wesam Almasri Hatim Abdelrahman Khalid Hussain Mohamed A. Hendaus Fatma Al-Mudahka Khaled Abouhazima Anthony K. Akobeng Rayaz A. Malik Corneal Langerhans cells in children with celiac disease Scientific Reports |
| title | Corneal Langerhans cells in children with celiac disease |
| title_full | Corneal Langerhans cells in children with celiac disease |
| title_fullStr | Corneal Langerhans cells in children with celiac disease |
| title_full_unstemmed | Corneal Langerhans cells in children with celiac disease |
| title_short | Corneal Langerhans cells in children with celiac disease |
| title_sort | corneal langerhans cells in children with celiac disease |
| url | https://doi.org/10.1038/s41598-022-22376-w |
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