Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study

Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study

Abstract Objective Aberrant expression in skeletal muscle of DUX4, a double homeobox transcription factor, underlies pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). Although previous studies of FSHD muscle biopsies detected mRNAs encoding DUX4 and its target genes, no studies had repo...

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Bibliographic Details
Main Authors: Mary Lou Beermann, Sachiko Homma, Jeffrey Boone Miller
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Research Notes
Subjects:
DUX4
Facioscapulohumeral muscular dystrophy
FSHD
Skeletal muscle biopsy
Proximity ligation assay
Online Access:https://doi.org/10.1186/s13104-022-06054-8

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