| Summary: | <i>Pseudomonas aeruginosa</i> can cause several life-threatening infections among immunocompromised patients (e.g., cystic fibrosis) due to its ability to adapt and develop resistance to several antibiotics. In recent years, <i>P. aeruginosa</i> infections has become difficult to treat using conventional antibiotics due to the increase multidrug-resistant <i>P. aeruginosa</i> strains. Therefore, there is a growing interest to develop novel treatments against antibiotic-resistance <i>P. aeruginosa</i> strains. One novel method includes the application of antimicrobial peptides secreted by <i>P. aeruginosa</i> strains, known as pyocins. In this review, we will discuss the structure, function, and use of pyocins in the pathogenesis and treatment of <i>P. aeruginosa</i> infection.
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