Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets
The carotid body (CB) is responsible for the peripheral chemoreflex by sensing blood gases and pH. The CB also appears to act as a peripheral sensor of metabolites and hormones, regulating the metabolism. CB malfunction induces aberrant chemosensory responses that culminate in the tonic overactivati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/14/5117 |
| _version_ | 1797561933376782336 |
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| author | Lenise J. Kim Vsevolod Y. Polotsky |
| author_facet | Lenise J. Kim Vsevolod Y. Polotsky |
| author_sort | Lenise J. Kim |
| collection | DOAJ |
| description | The carotid body (CB) is responsible for the peripheral chemoreflex by sensing blood gases and pH. The CB also appears to act as a peripheral sensor of metabolites and hormones, regulating the metabolism. CB malfunction induces aberrant chemosensory responses that culminate in the tonic overactivation of the sympathetic nervous system. The sympatho-excitation evoked by CB may contribute to the pathogenesis of metabolic syndrome, inducing systemic hypertension, insulin resistance and sleep-disordered breathing. Several molecular pathways are involved in the modulation of CB activity, and their pharmacological manipulation may lead to overall benefits for cardiometabolic diseases. In this review, we will discuss the role of the CB in the regulation of metabolism and in the pathogenesis of the metabolic dysfunction induced by CB overactivity. We will also explore the potential pharmacological targets in the CB for the treatment of metabolic syndrome. |
| first_indexed | 2024-03-10T18:21:25Z |
| format | Article |
| id | doaj.art-2391a4ce495645f09f2fec80b82f0eca |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:21:25Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2391a4ce495645f09f2fec80b82f0eca2023-11-20T07:18:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114511710.3390/ijms21145117Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic TargetsLenise J. Kim0Vsevolod Y. Polotsky1Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USAThe carotid body (CB) is responsible for the peripheral chemoreflex by sensing blood gases and pH. The CB also appears to act as a peripheral sensor of metabolites and hormones, regulating the metabolism. CB malfunction induces aberrant chemosensory responses that culminate in the tonic overactivation of the sympathetic nervous system. The sympatho-excitation evoked by CB may contribute to the pathogenesis of metabolic syndrome, inducing systemic hypertension, insulin resistance and sleep-disordered breathing. Several molecular pathways are involved in the modulation of CB activity, and their pharmacological manipulation may lead to overall benefits for cardiometabolic diseases. In this review, we will discuss the role of the CB in the regulation of metabolism and in the pathogenesis of the metabolic dysfunction induced by CB overactivity. We will also explore the potential pharmacological targets in the CB for the treatment of metabolic syndrome.https://www.mdpi.com/1422-0067/21/14/5117carotid bodymetabolic syndromehypertensionglucose metabolismsleep-disordered breathingobesity |
| spellingShingle | Lenise J. Kim Vsevolod Y. Polotsky Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets International Journal of Molecular Sciences carotid body metabolic syndrome hypertension glucose metabolism sleep-disordered breathing obesity |
| title | Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets |
| title_full | Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets |
| title_fullStr | Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets |
| title_full_unstemmed | Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets |
| title_short | Carotid Body and Metabolic Syndrome: Mechanisms and Potential Therapeutic Targets |
| title_sort | carotid body and metabolic syndrome mechanisms and potential therapeutic targets |
| topic | carotid body metabolic syndrome hypertension glucose metabolism sleep-disordered breathing obesity |
| url | https://www.mdpi.com/1422-0067/21/14/5117 |
| work_keys_str_mv | AT lenisejkim carotidbodyandmetabolicsyndromemechanismsandpotentialtherapeutictargets AT vsevolodypolotsky carotidbodyandmetabolicsyndromemechanismsandpotentialtherapeutictargets |