No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis
This study sought to assess the association between illicit opioid use and accelerated epigenetic aging (A.K.A. DNAm Age) among people of African ancestry who use heroin. DNA was obtained from participants with opioid use disorder (OUD) who confirmed heroin as their primary drug of choice. Clinical...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Addiction Neuroscience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392523000391 |
| _version_ | 1797801621461139456 |
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| author | Jermaine D. Jones Suky Martinez Ingrid Gonzalez Gabriel J. Odom Sandra D. Comer |
| author_facet | Jermaine D. Jones Suky Martinez Ingrid Gonzalez Gabriel J. Odom Sandra D. Comer |
| author_sort | Jermaine D. Jones |
| collection | DOAJ |
| description | This study sought to assess the association between illicit opioid use and accelerated epigenetic aging (A.K.A. DNAm Age) among people of African ancestry who use heroin. DNA was obtained from participants with opioid use disorder (OUD) who confirmed heroin as their primary drug of choice. Clinical inventories of drug use included: the Addiction Severity Index (ASI) Drug-Composite Score (range: 0–1), and Drug Abuse Screening Test (DAST-10; range: 0–10). A control group of participants of African ancestry who did not use heroin was recruited and matched to heroin users on sex, age, socioeconomic level, and smoking status. Methylation data were assessed in an epigenetic clock to determined and compare Epigenetic Age to Chronological Age (i.e., age acceleration or deceleration). Data were obtained from 32 controls [mean age 36.3 (±7.5) years] and 64 heroin users [mean age 48.1 (±6.6) years]. The experimental group used heroin for an average of 18.1 (±10.6) years, reported use of 6.4 (±6.1) bags of heroin/day, with a mean DAST-10 score of 7.0 (±2.6) and ASI Score of 0.33 (±0.19). Mean age acceleration for heroin users [+0.56 (± 9.5) years] was significantly (p< 0.05) lower than controls [+5.19 (± 9.1) years]. This study did not find evidence that heroin use causes epigenetic age acceleration. |
| first_indexed | 2024-03-13T04:53:16Z |
| format | Article |
| id | doaj.art-239267a008f8410db8c66ab8642b33fb |
| institution | Directory Open Access Journal |
| issn | 2772-3925 |
| language | English |
| last_indexed | 2024-03-13T04:53:16Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj.art-239267a008f8410db8c66ab8642b33fb2023-06-18T05:04:05ZengElsevierAddiction Neuroscience2772-39252023-09-017100096No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysisJermaine D. Jones0Suky Martinez1Ingrid Gonzalez2Gabriel J. Odom3Sandra D. Comer4Department of Psychiatry, Division on Substance Use Disorders, New York State Psychiatric Institute, and Columbia University Irving Medical Center, 1051 Riverside Drive, New York, NY 10032, USA; Corresponding author.Department of Psychiatry, Division on Substance Use Disorders, New York State Psychiatric Institute, and Columbia University Irving Medical Center, 1051 Riverside Drive, New York, NY 10032, USADepartment of Biostatistics, Robert Stempel College of Public Health, Florida International University, 1200 SW 8th St, Miami, FL 33174, USADepartment of Biostatistics, Robert Stempel College of Public Health, Florida International University, 1200 SW 8th St, Miami, FL 33174, USADepartment of Psychiatry, Division on Substance Use Disorders, New York State Psychiatric Institute, and Columbia University Irving Medical Center, 1051 Riverside Drive, New York, NY 10032, USAThis study sought to assess the association between illicit opioid use and accelerated epigenetic aging (A.K.A. DNAm Age) among people of African ancestry who use heroin. DNA was obtained from participants with opioid use disorder (OUD) who confirmed heroin as their primary drug of choice. Clinical inventories of drug use included: the Addiction Severity Index (ASI) Drug-Composite Score (range: 0–1), and Drug Abuse Screening Test (DAST-10; range: 0–10). A control group of participants of African ancestry who did not use heroin was recruited and matched to heroin users on sex, age, socioeconomic level, and smoking status. Methylation data were assessed in an epigenetic clock to determined and compare Epigenetic Age to Chronological Age (i.e., age acceleration or deceleration). Data were obtained from 32 controls [mean age 36.3 (±7.5) years] and 64 heroin users [mean age 48.1 (±6.6) years]. The experimental group used heroin for an average of 18.1 (±10.6) years, reported use of 6.4 (±6.1) bags of heroin/day, with a mean DAST-10 score of 7.0 (±2.6) and ASI Score of 0.33 (±0.19). Mean age acceleration for heroin users [+0.56 (± 9.5) years] was significantly (p< 0.05) lower than controls [+5.19 (± 9.1) years]. This study did not find evidence that heroin use causes epigenetic age acceleration.http://www.sciencedirect.com/science/article/pii/S2772392523000391 |
| spellingShingle | Jermaine D. Jones Suky Martinez Ingrid Gonzalez Gabriel J. Odom Sandra D. Comer No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis Addiction Neuroscience |
| title | No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis |
| title_full | No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis |
| title_fullStr | No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis |
| title_full_unstemmed | No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis |
| title_short | No evidence of accelerated epigenetic aging among black heroin users: A case vs control analysis |
| title_sort | no evidence of accelerated epigenetic aging among black heroin users a case vs control analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2772392523000391 |
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