Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study
BackgroundPatients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this study...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1176204/full |
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| author | Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Angeles Cánovas-Molina Angeles Cánovas-Molina Angeles Cánovas-Molina Juan A. Díaz-Garrido Silvia Cañas Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Horus Laffite Mario Federico Delvys Rodríguez-Abreu Saray Galván Carla García-Lourve Carla García-Lourve Damián González-Beltrán Miguel A. Caramés Jose L. Hernández-Fleta Pedro Serrano-Aguilar Pedro Serrano-Aguilar Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón |
| author_facet | Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Angeles Cánovas-Molina Angeles Cánovas-Molina Angeles Cánovas-Molina Juan A. Díaz-Garrido Silvia Cañas Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Horus Laffite Mario Federico Delvys Rodríguez-Abreu Saray Galván Carla García-Lourve Carla García-Lourve Damián González-Beltrán Miguel A. Caramés Jose L. Hernández-Fleta Pedro Serrano-Aguilar Pedro Serrano-Aguilar Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón |
| author_sort | Bernardino Clavo |
| collection | DOAJ |
| description | BackgroundPatients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this study was to preliminarily evaluate, in patients treated because of refractory symptoms of cancer treatment and advanced nononcologic diseases, if ozone therapy has an additional impact on self-reported anxiety and depression.MethodsBefore and after ozone treatment, we assessed (i) anxiety and depression according to the Hospital Anxiety and Depression Scale (HADS); (ii) the HRQOL (according to the EQ-5D-5L questionnaire), which includes a dimension on anxiety and depression and a visual analog scale (VAS) measuring self-perceived general health.ResultsBefore ozone therapy, 56% of patients were on anxiolytic and/or antidepressant treatment. Before and after ozone therapy, the anxiety and depression HADS subscales (i) significantly correlated with the anxiety/depression dimension of the EQ-5D-5L questionnaire and (ii) inversely correlated with the health status as measured by the VAS. After ozone therapy, we found a significant improvement in anxiety and depression measured by both the (i) HADS subscales and (ii) EQ-5D-5L questionnaire.ConclusionThe addition of ozone therapy for patients with refractory symptoms of cancer treatment and advanced chronic nononcologic diseases can decrease anxiety and depression severity levels. Additional, more focused studies are ongoing to provide the needed explanatory information for this finding. |
| first_indexed | 2024-03-12T17:33:20Z |
| format | Article |
| id | doaj.art-2392e3846ef54a5cb83f785bff2d0ecc |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-03-12T17:33:20Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-2392e3846ef54a5cb83f785bff2d0ecc2023-08-04T15:32:34ZengFrontiers Media S.A.Frontiers in Psychology1664-10782023-08-011410.3389/fpsyg.2023.11762041176204Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot studyBernardino Clavo0Bernardino Clavo1Bernardino Clavo2Bernardino Clavo3Bernardino Clavo4Bernardino Clavo5Bernardino Clavo6Bernardino Clavo7Angeles Cánovas-Molina8Angeles Cánovas-Molina9Angeles Cánovas-Molina10Juan A. Díaz-Garrido11Silvia Cañas12Yolanda Ramallo-Fariña13Yolanda Ramallo-Fariña14Yolanda Ramallo-Fariña15Yolanda Ramallo-Fariña16Horus Laffite17Mario Federico18Delvys Rodríguez-Abreu19Saray Galván20Carla García-Lourve21Carla García-Lourve22Damián González-Beltrán23Miguel A. Caramés24Jose L. Hernández-Fleta25Pedro Serrano-Aguilar26Pedro Serrano-Aguilar27Francisco Rodríguez-Esparragón28Francisco Rodríguez-Esparragón29Francisco Rodríguez-Esparragón30Francisco Rodríguez-Esparragón31Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainChronic Pain Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainRadiation Oncology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, SpainUniversitary Institute for Research in Biomedicine and Health (iUIBS), Molecular and Translational Pharmacology Group, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, SpainInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias de la Universidad de La Laguna, Santa Cruz de Tenerife, SpainCIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainSpanish Group of Clinical Research in Radiation Oncology (GICOR), Madrid, SpainResearch Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainChronic Pain Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, SpainPsychiatry Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain0Psychiatry Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, Spain1Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Santa Cruz de Tenerife, Spain2Servicio de Evaluación y Planificación del Servicio Canario de Salud (SESCS), Santa Cruz de Tenerife, Spain3Instituto de Tecnologías Biomédicas (ITB), Universidad de la Laguna, Santa Cruz de Tenerife, SpainPsychiatry Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainRadiation Oncology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain4Medical Oncology Department, Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas de Gran Canaria, Spain5Medical Oncology Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainResearch Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, SpainResearch Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainChronic Pain Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainPsychiatry Department, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, Spain3Instituto de Tecnologías Biomédicas (ITB), Universidad de la Laguna, Santa Cruz de Tenerife, SpainResearch Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, SpainFundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria/Tenerife, SpainInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias de la Universidad de La Laguna, Santa Cruz de Tenerife, SpainCIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, SpainBackgroundPatients with refractory symptoms of severe diseases frequently experience anxiety, depression, and an altered health-related quality of life (HRQOL). Some publications have described the beneficial effect of ozone therapy on several symptoms of this kind of patient. The aim of this study was to preliminarily evaluate, in patients treated because of refractory symptoms of cancer treatment and advanced nononcologic diseases, if ozone therapy has an additional impact on self-reported anxiety and depression.MethodsBefore and after ozone treatment, we assessed (i) anxiety and depression according to the Hospital Anxiety and Depression Scale (HADS); (ii) the HRQOL (according to the EQ-5D-5L questionnaire), which includes a dimension on anxiety and depression and a visual analog scale (VAS) measuring self-perceived general health.ResultsBefore ozone therapy, 56% of patients were on anxiolytic and/or antidepressant treatment. Before and after ozone therapy, the anxiety and depression HADS subscales (i) significantly correlated with the anxiety/depression dimension of the EQ-5D-5L questionnaire and (ii) inversely correlated with the health status as measured by the VAS. After ozone therapy, we found a significant improvement in anxiety and depression measured by both the (i) HADS subscales and (ii) EQ-5D-5L questionnaire.ConclusionThe addition of ozone therapy for patients with refractory symptoms of cancer treatment and advanced chronic nononcologic diseases can decrease anxiety and depression severity levels. Additional, more focused studies are ongoing to provide the needed explanatory information for this finding.https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1176204/fullozone therapyanxiety and depressionhealth-related quality of lifeadvanced diseaseschemotherapy-induced side effectsradiation-induced side effects |
| spellingShingle | Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Bernardino Clavo Angeles Cánovas-Molina Angeles Cánovas-Molina Angeles Cánovas-Molina Juan A. Díaz-Garrido Silvia Cañas Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Yolanda Ramallo-Fariña Horus Laffite Mario Federico Delvys Rodríguez-Abreu Saray Galván Carla García-Lourve Carla García-Lourve Damián González-Beltrán Miguel A. Caramés Jose L. Hernández-Fleta Pedro Serrano-Aguilar Pedro Serrano-Aguilar Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón Francisco Rodríguez-Esparragón Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study Frontiers in Psychology ozone therapy anxiety and depression health-related quality of life advanced diseases chemotherapy-induced side effects radiation-induced side effects |
| title | Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study |
| title_full | Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study |
| title_fullStr | Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study |
| title_full_unstemmed | Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study |
| title_short | Effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases: a pilot study |
| title_sort | effects of ozone therapy on anxiety and depression in patients with refractory symptoms of severe diseases a pilot study |
| topic | ozone therapy anxiety and depression health-related quality of life advanced diseases chemotherapy-induced side effects radiation-induced side effects |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1176204/full |
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