Diacylglycerol kinases in the coordination of synaptic plasticity
Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00092/full |
| _version_ | 1818131695771058176 |
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| author | Dongwon Lee Eunjoon Kim Eunjoon Kim Keiko Tanaka-Yamamoto |
| author_facet | Dongwon Lee Eunjoon Kim Eunjoon Kim Keiko Tanaka-Yamamoto |
| author_sort | Dongwon Lee |
| collection | DOAJ |
| description | Synaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Recent evidence indicate that DAG kinases (DGKs), which phosphorylate DAG to phosphatidic acid to terminate DAG signaling, are important regulators of LTP and LTD, as supported by the results from mice lacking specific DGK isoforms. This review will summarize these studies and discuss how specific DGK isoforms distinctly regulate different forms of synaptic plasticity at pre- and postsynaptic sites. In addition, we propose a general role of DGKs as coordinators of synaptic plasticity that make local synaptic environments more permissive for synaptic plasticity by regulating DAG concentration and interacting with other synaptic proteins. |
| first_indexed | 2024-12-11T08:25:02Z |
| format | Article |
| id | doaj.art-23932fea27b9446f84a4417fed197541 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-11T08:25:02Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-23932fea27b9446f84a4417fed1975412022-12-22T01:14:34ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2016-08-01410.3389/fcell.2016.00092214603Diacylglycerol kinases in the coordination of synaptic plasticityDongwon Lee0Eunjoon Kim1Eunjoon Kim2Keiko Tanaka-Yamamoto3Institute for Basic ScienceInstitute for Basic ScienceDepartment of Biological SciencesKorea Institute of Science and TechnologySynaptic plasticity is activity-dependent modification of the efficacy of synaptic transmission. Although detailed mechanisms underlying synaptic plasticity are diverse and vary at different types of synapses, diacylglycerol (DAG)-associated signaling has been considered as an important regulator of many forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). Recent evidence indicate that DAG kinases (DGKs), which phosphorylate DAG to phosphatidic acid to terminate DAG signaling, are important regulators of LTP and LTD, as supported by the results from mice lacking specific DGK isoforms. This review will summarize these studies and discuss how specific DGK isoforms distinctly regulate different forms of synaptic plasticity at pre- and postsynaptic sites. In addition, we propose a general role of DGKs as coordinators of synaptic plasticity that make local synaptic environments more permissive for synaptic plasticity by regulating DAG concentration and interacting with other synaptic proteins.http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00092/fullDiacylglycerol KinaseLong-Term PotentiationProtein Kinase Csynaptic plasticityLong-term depression |
| spellingShingle | Dongwon Lee Eunjoon Kim Eunjoon Kim Keiko Tanaka-Yamamoto Diacylglycerol kinases in the coordination of synaptic plasticity Frontiers in Cell and Developmental Biology Diacylglycerol Kinase Long-Term Potentiation Protein Kinase C synaptic plasticity Long-term depression |
| title | Diacylglycerol kinases in the coordination of synaptic plasticity |
| title_full | Diacylglycerol kinases in the coordination of synaptic plasticity |
| title_fullStr | Diacylglycerol kinases in the coordination of synaptic plasticity |
| title_full_unstemmed | Diacylglycerol kinases in the coordination of synaptic plasticity |
| title_short | Diacylglycerol kinases in the coordination of synaptic plasticity |
| title_sort | diacylglycerol kinases in the coordination of synaptic plasticity |
| topic | Diacylglycerol Kinase Long-Term Potentiation Protein Kinase C synaptic plasticity Long-term depression |
| url | http://journal.frontiersin.org/Journal/10.3389/fcell.2016.00092/full |
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