Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in Mice
MCTs is an important component of fat emulsion for special medical purposes (FESMP), and palm kernel oil is the natural food source of MCTs. In order to develop palm kernel oil based FESMP, the oil phase formula of the emulsion was designed according to the General Rules of Formula Food for Special...
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Academy of National Food and Strategic Reserves Administration
2022-03-01
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| Series: | Liang you shipin ke-ji |
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| Online Access: | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20220213?st=article_issue |
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| author | ZHU Hai-hua GE Rui-hong MA Yin-hui YANG Jun-hao WANG Yong WANG Hui |
| author_facet | ZHU Hai-hua GE Rui-hong MA Yin-hui YANG Jun-hao WANG Yong WANG Hui |
| author_sort | ZHU Hai-hua |
| collection | DOAJ |
| description | MCTs is an important component of fat emulsion for special medical purposes (FESMP), and palm kernel oil is the natural food source of MCTs. In order to develop palm kernel oil based FESMP, the oil phase formula of the emulsion was designed according to the General Rules of Formula Food for Special Medical Use and the Reference Dietary Nutrient Intake of Chinese Residents, and the fatty acid composition was analyzed. The preparation process of fat emulsion was optimized by Zeta potential and particle size, the stability was evaluated and the effect on serum lipid was studied in mice. The results showed that the ratio of n–6 to n–3 in oil phase was 5.16±0.05; Step-by-step emulsification method was adopted, and the optimal emulsification process parameters were as follows: emulsification speed of 10 000 r/min, emulsification time of 20 min, and emulsification temperature of 50 ℃. The initial emulsion was homogenized by high pressure homogenizer at 50 MPa for three times and autoclaved at 121 ℃ for 10 min, and the product quality was stable. The results of animal experiments showed that the fatty acid balanced emulsion could significantly reduce the content of Triglycerides (TG) in serum of mice (P<0.01), and reduce the content of Total cholesterol (TC) in serum (P<0.01). It can also reduce the Low-density lipoprotein cholesterol, LDL-C content (P<0.05) and increase the content of High-density lipoprotein cholesterol (HDL-C) (P<0.01). Therefore, it has a certain significance for regulating the level of blood lipid. |
| first_indexed | 2024-04-09T17:30:02Z |
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| id | doaj.art-2394b2c509144d9a8738f84b2b57de87 |
| institution | Directory Open Access Journal |
| issn | 1007-7561 |
| language | English |
| last_indexed | 2024-04-09T17:30:02Z |
| publishDate | 2022-03-01 |
| publisher | Academy of National Food and Strategic Reserves Administration |
| record_format | Article |
| series | Liang you shipin ke-ji |
| spelling | doaj.art-2394b2c509144d9a8738f84b2b57de872023-04-18T06:12:10ZengAcademy of National Food and Strategic Reserves AdministrationLiang you shipin ke-ji1007-75612022-03-01302849410.16210/j.cnki.1007-7561.2022.02.011Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in MiceZHU Hai-hua0GE Rui-hong1MA Yin-hui2YANG Jun-hao3WANG Yong4WANG Hui5Henan Commerce Science Institute Co., Ltd., Zhengzhou, Henan 450002, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, ChinaPalm Oil Research and Technical Service Institute of Malaysian Palm Oil Board, Shanghai 201108, ChinaPalm Oil Research and Technical Service Institute of Malaysian Palm Oil Board, Shanghai 201108, ChinaHenan Commerce Science Institute Co., Ltd., Zhengzhou, Henan 450002, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaMCTs is an important component of fat emulsion for special medical purposes (FESMP), and palm kernel oil is the natural food source of MCTs. In order to develop palm kernel oil based FESMP, the oil phase formula of the emulsion was designed according to the General Rules of Formula Food for Special Medical Use and the Reference Dietary Nutrient Intake of Chinese Residents, and the fatty acid composition was analyzed. The preparation process of fat emulsion was optimized by Zeta potential and particle size, the stability was evaluated and the effect on serum lipid was studied in mice. The results showed that the ratio of n–6 to n–3 in oil phase was 5.16±0.05; Step-by-step emulsification method was adopted, and the optimal emulsification process parameters were as follows: emulsification speed of 10 000 r/min, emulsification time of 20 min, and emulsification temperature of 50 ℃. The initial emulsion was homogenized by high pressure homogenizer at 50 MPa for three times and autoclaved at 121 ℃ for 10 min, and the product quality was stable. The results of animal experiments showed that the fatty acid balanced emulsion could significantly reduce the content of Triglycerides (TG) in serum of mice (P<0.01), and reduce the content of Total cholesterol (TC) in serum (P<0.01). It can also reduce the Low-density lipoprotein cholesterol, LDL-C content (P<0.05) and increase the content of High-density lipoprotein cholesterol (HDL-C) (P<0.01). Therefore, it has a certain significance for regulating the level of blood lipid.http://lyspkj.ijournal.cn/lyspkj/article/abstract/20220213?st=article_issuemedium chain triglyceridespalm kernel oilfatty acid equilibriumemulsification processfat emulsion for special medical purposesregulating blood lipid |
| spellingShingle | ZHU Hai-hua GE Rui-hong MA Yin-hui YANG Jun-hao WANG Yong WANG Hui Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in Mice Liang you shipin ke-ji medium chain triglycerides palm kernel oil fatty acid equilibrium emulsification process fat emulsion for special medical purposes regulating blood lipid |
| title | Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in Mice |
| title_full | Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in Mice |
| title_fullStr | Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in Mice |
| title_full_unstemmed | Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in Mice |
| title_short | Preparation of Special Medical Fat Emulsion Based on Palm Kernel Oil and its Effect on Blood Lipid in Mice |
| title_sort | preparation of special medical fat emulsion based on palm kernel oil and its effect on blood lipid in mice |
| topic | medium chain triglycerides palm kernel oil fatty acid equilibrium emulsification process fat emulsion for special medical purposes regulating blood lipid |
| url | http://lyspkj.ijournal.cn/lyspkj/article/abstract/20220213?st=article_issue |
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