Remus: System for remote deep brain interventions
Summary: Transcranial-focused ultrasound brings personalized medicine to the human brain. Ultrasound can modulate neural activity or release drugs in specific neural circuits but this personalized approach requires a system that delivers ultrasound into specified targets flexibly and on command. We...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222015231 |
| _version_ | 1797990899712524288 |
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| author | Taylor D. Webb Matthew G. Wilson Henrik Odéen Jan Kubanek |
| author_facet | Taylor D. Webb Matthew G. Wilson Henrik Odéen Jan Kubanek |
| author_sort | Taylor D. Webb |
| collection | DOAJ |
| description | Summary: Transcranial-focused ultrasound brings personalized medicine to the human brain. Ultrasound can modulate neural activity or release drugs in specific neural circuits but this personalized approach requires a system that delivers ultrasound into specified targets flexibly and on command. We developed a remote ultrasound system (Remus) that programmatically targets deep brain regions with high spatiotemporal precision and in a multi-focal manner. We validated these functions by modulating two deep brain nuclei—the left and right lateral geniculate nucleus—in a task-performing nonhuman primate. This flexible system will enable researchers and clinicians to diagnose and treat specific deep brain circuits in a noninvasive yet targeted manner, thus embodying the promise of personalized treatments of brain disorders. |
| first_indexed | 2024-04-11T08:43:55Z |
| format | Article |
| id | doaj.art-239692382fb44df4929de0784ac51752 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-11T08:43:55Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-239692382fb44df4929de0784ac517522022-12-22T04:34:02ZengElsevieriScience2589-00422022-11-012511105251Remus: System for remote deep brain interventionsTaylor D. Webb0Matthew G. Wilson1Henrik Odéen2Jan Kubanek3Department of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA; Corresponding authorDepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USADepartment of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USADepartment of Biomedical Engineering, University of Utah, Salt Lake City, Utah, USA; Corresponding authorSummary: Transcranial-focused ultrasound brings personalized medicine to the human brain. Ultrasound can modulate neural activity or release drugs in specific neural circuits but this personalized approach requires a system that delivers ultrasound into specified targets flexibly and on command. We developed a remote ultrasound system (Remus) that programmatically targets deep brain regions with high spatiotemporal precision and in a multi-focal manner. We validated these functions by modulating two deep brain nuclei—the left and right lateral geniculate nucleus—in a task-performing nonhuman primate. This flexible system will enable researchers and clinicians to diagnose and treat specific deep brain circuits in a noninvasive yet targeted manner, thus embodying the promise of personalized treatments of brain disorders.http://www.sciencedirect.com/science/article/pii/S2589004222015231Biological sciencesBiotechnologyAnimal biotechnologyBiodevices |
| spellingShingle | Taylor D. Webb Matthew G. Wilson Henrik Odéen Jan Kubanek Remus: System for remote deep brain interventions iScience Biological sciences Biotechnology Animal biotechnology Biodevices |
| title | Remus: System for remote deep brain interventions |
| title_full | Remus: System for remote deep brain interventions |
| title_fullStr | Remus: System for remote deep brain interventions |
| title_full_unstemmed | Remus: System for remote deep brain interventions |
| title_short | Remus: System for remote deep brain interventions |
| title_sort | remus system for remote deep brain interventions |
| topic | Biological sciences Biotechnology Animal biotechnology Biodevices |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222015231 |
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