Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway
Abstract Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway has emerged as a crucial contributor to the development, advancement, and resistance to treatment. This revie...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-04841-w |
| _version_ | 1797362898969821184 |
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| author | Muhammad Tufail Jia-Ju Hu Jie Liang Cai-Yun He Wen-Dong Wan Yu-Qi Huang Can-Hua Jiang Hong Wu Ning Li |
| author_facet | Muhammad Tufail Jia-Ju Hu Jie Liang Cai-Yun He Wen-Dong Wan Yu-Qi Huang Can-Hua Jiang Hong Wu Ning Li |
| author_sort | Muhammad Tufail |
| collection | DOAJ |
| description | Abstract Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway has emerged as a crucial contributor to the development, advancement, and resistance to treatment. This review article explores the implications of the PI3K pathway in predictive, preventive, and personalized medicine for BC. It emphasizes the identification of predictive biomarkers, such as PIK3CA mutations, and the utility of molecular profiling in guiding treatment decisions. The review also discusses the potential of targeting the PI3K pathway for preventive strategies and the customization of therapy based on tumor stage, molecular subtypes, and genetic alterations. Overcoming resistance to PI3K inhibitors and exploring combination therapies are addressed as important considerations. While this field holds promise in improving patient outcomes, further research and clinical trials are needed to validate these approaches and translate them into clinical practice. Graphical Abstract |
| first_indexed | 2024-03-08T16:14:03Z |
| format | Article |
| id | doaj.art-239713b991c34254abd3e619329703cb |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-08T16:14:03Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-239713b991c34254abd3e619329703cb2024-01-07T12:42:16ZengBMCJournal of Translational Medicine1479-58762024-01-0122113710.1186/s12967-023-04841-wPredictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathwayMuhammad Tufail0Jia-Ju Hu1Jie Liang2Cai-Yun He3Wen-Dong Wan4Yu-Qi Huang5Can-Hua Jiang6Hong Wu7Ning Li8Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityState Key Laboratory of Powder Metallurgy, Central South UniversityDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South UniversityAbstract Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway has emerged as a crucial contributor to the development, advancement, and resistance to treatment. This review article explores the implications of the PI3K pathway in predictive, preventive, and personalized medicine for BC. It emphasizes the identification of predictive biomarkers, such as PIK3CA mutations, and the utility of molecular profiling in guiding treatment decisions. The review also discusses the potential of targeting the PI3K pathway for preventive strategies and the customization of therapy based on tumor stage, molecular subtypes, and genetic alterations. Overcoming resistance to PI3K inhibitors and exploring combination therapies are addressed as important considerations. While this field holds promise in improving patient outcomes, further research and clinical trials are needed to validate these approaches and translate them into clinical practice. Graphical Abstracthttps://doi.org/10.1186/s12967-023-04841-wBreast cancerPI3K pathwayPredictive medicinePreventive medicinePersonalized medicine |
| spellingShingle | Muhammad Tufail Jia-Ju Hu Jie Liang Cai-Yun He Wen-Dong Wan Yu-Qi Huang Can-Hua Jiang Hong Wu Ning Li Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway Journal of Translational Medicine Breast cancer PI3K pathway Predictive medicine Preventive medicine Personalized medicine |
| title | Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway |
| title_full | Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway |
| title_fullStr | Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway |
| title_full_unstemmed | Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway |
| title_short | Predictive, preventive, and personalized medicine in breast cancer: targeting the PI3K pathway |
| title_sort | predictive preventive and personalized medicine in breast cancer targeting the pi3k pathway |
| topic | Breast cancer PI3K pathway Predictive medicine Preventive medicine Personalized medicine |
| url | https://doi.org/10.1186/s12967-023-04841-w |
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