A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological Malignancies
Objective: Non-responsiveness to hepatitis B virus (HBV) vaccines is not rare in hemato-oncological patients due to disease-associated or treatment-induced immune suppression. Although different strategies have been employed to improve the response rates, to date there is not an approved schedule fo...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2016-08-01
|
| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-43410 |
| _version_ | 1828021597598908416 |
|---|---|
| author | Zübeyde Nur Özkurt Elif Suyanı Rauf Haznedar Münci Yağcı |
| author_facet | Zübeyde Nur Özkurt Elif Suyanı Rauf Haznedar Münci Yağcı |
| author_sort | Zübeyde Nur Özkurt |
| collection | DOAJ |
| description | Objective: Non-responsiveness to hepatitis B virus (HBV) vaccines is not rare in hemato-oncological patients due to disease-associated or treatment-induced immune suppression. Although different strategies have been employed to improve the response rates, to date there is not an approved schedule for HBV immunization in patients with hematological malignancies. We designed a prospective randomized study to evaluate the efficacy of 3 different induction regimens for HBV vaccination. Materials and Methods: In the standard-dose (SD) group, total vaccine dose delivered was 40 μg and patients were vaccinated with 20 μg at weeks 0 and 4. In the high-dose dose-intensive (HDDI) group, total vaccine dose delivered was 80 μg and patients were vaccinated with 40 μg at weeks 0 and 4. In the high-dose time-intensive (HDTI) group, total vaccine dose delivered was 80 μg and patients were vaccinated with 20 μg at weeks 0, 2, 4, and 6. Results: In a cohort of 114 patients, 38.6% responded to HBV vaccination. The response rate in the SD arm, HDDI arm, and HDTI arm was 26.2%, 29.7%, and 44.4%, respectively (p>0.05). Age was the only variable identified as having a negative impact on response. Conclusion: Short of achieving statistical significance, a higher response rate was observed in the HDTI arm. Therefore, this study supports a high-dose, time-intensive HBV vaccine induction regimen in patients with hematological malignancies who are not on chemotherapy. |
| first_indexed | 2024-04-10T11:55:36Z |
| format | Article |
| id | doaj.art-239906aebeee4a32b124c7bd9ea138ca |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:55:36Z |
| publishDate | 2016-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-239906aebeee4a32b124c7bd9ea138ca2023-02-15T16:16:48ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632016-08-0133323123510.4274/tjh.2015.0079TJH-43410A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological MalignanciesZübeyde Nur Özkurt0Elif Suyanı1Rauf Haznedar2Münci Yağcı3Gazi University Faculty of Medicine, Department of Hematology, Ankara, TurkeyGazi University Faculty of Medicine, Department of Hematology, Ankara, TurkeyGazi University Faculty of Medicine, Department of Hematology, Ankara, TurkeyGazi University Faculty of Medicine, Department of Hematology, Ankara, TurkeyObjective: Non-responsiveness to hepatitis B virus (HBV) vaccines is not rare in hemato-oncological patients due to disease-associated or treatment-induced immune suppression. Although different strategies have been employed to improve the response rates, to date there is not an approved schedule for HBV immunization in patients with hematological malignancies. We designed a prospective randomized study to evaluate the efficacy of 3 different induction regimens for HBV vaccination. Materials and Methods: In the standard-dose (SD) group, total vaccine dose delivered was 40 μg and patients were vaccinated with 20 μg at weeks 0 and 4. In the high-dose dose-intensive (HDDI) group, total vaccine dose delivered was 80 μg and patients were vaccinated with 40 μg at weeks 0 and 4. In the high-dose time-intensive (HDTI) group, total vaccine dose delivered was 80 μg and patients were vaccinated with 20 μg at weeks 0, 2, 4, and 6. Results: In a cohort of 114 patients, 38.6% responded to HBV vaccination. The response rate in the SD arm, HDDI arm, and HDTI arm was 26.2%, 29.7%, and 44.4%, respectively (p>0.05). Age was the only variable identified as having a negative impact on response. Conclusion: Short of achieving statistical significance, a higher response rate was observed in the HDTI arm. Therefore, this study supports a high-dose, time-intensive HBV vaccine induction regimen in patients with hematological malignancies who are not on chemotherapy.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-43410hepatitis bvaccinehematological malignancies |
| spellingShingle | Zübeyde Nur Özkurt Elif Suyanı Rauf Haznedar Münci Yağcı A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological Malignancies Turkish Journal of Hematology hepatitis b vaccine hematological malignancies |
| title | A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological Malignancies |
| title_full | A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological Malignancies |
| title_fullStr | A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological Malignancies |
| title_full_unstemmed | A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological Malignancies |
| title_short | A Randomized Study Comparing the Efficacy of Three Hepatitis B Vaccine Induction Regimens in Adult Patients with Hematological Malignancies |
| title_sort | randomized study comparing the efficacy of three hepatitis b vaccine induction regimens in adult patients with hematological malignancies |
| topic | hepatitis b vaccine hematological malignancies |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-43410 |
| work_keys_str_mv | AT zubeydenurozkurt arandomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies AT elifsuyanı arandomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies AT raufhaznedar arandomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies AT munciyagcı arandomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies AT zubeydenurozkurt randomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies AT elifsuyanı randomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies AT raufhaznedar randomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies AT munciyagcı randomizedstudycomparingtheefficacyofthreehepatitisbvaccineinductionregimensinadultpatientswithhematologicalmalignancies |