Investigation of the Effect on the Albumin Binding Moiety for the Pharmacokinetic Properties of <sup>68</sup>Ga-, <sup>205/206</sup>Bi-, and <sup>177</sup>Lu-Labeled NAPamide-Based Radiopharmaceuticals

Investigation of the Effect on the Albumin Binding Moiety for the Pharmacokinetic Properties of <sup>68</sup>Ga-, <sup>205/206</sup>Bi-, and <sup>177</sup>Lu-Labeled NAPamide-Based Radiopharmaceuticals

Although radiolabeled alpha-melanocyte stimulating hormone-analogue NAPamide derivatives are valuable melanoma-specific diagnostic probes, their rapid elimination kinetics and high renal uptake may preclude them from being used in clinical settings. We aimed at improving the pharmacokinetics of radi...

Full description

Bibliographic Details
Main Authors: Dániel Szücs, Judit P. Szabó, Viktória Arató, Barbara Gyuricza, Dezső Szikra, Imre Tóth, Zita Képes, György Trencsényi, Anikó Fekete
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
albumin-binding moiety
malignant melanoma (MM)
melanocortin-1 receptor (MC1-R)
NAPamide
positron emission tomography (PET)
radiolabeling
Online Access:https://www.mdpi.com/1424-8247/16/9/1280

Internet

https://www.mdpi.com/1424-8247/16/9/1280

Similar Items