Comparison of P6 Acupoint Stimulation, Ondansetron and Dexamethasone for Prevention of Postoperative Nausea and Vomiting after Laparoscopic Surgeries: A Randomised Clinical Study
Introduction: Non pharmacological techniques have an established role in treatment of chronic pain and related conditions. A few non pharmacological techniques have been employed to avoid the adverse effects of drugs. They have also proven to be cost-effective. Liberal fluid administration is th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18212/61675_CE[Ra1]_F(IS)_PF1(HB_IS_OM)_PFA(HB_KM)_PN(KM).pdf |
| Summary: | Introduction: Non pharmacological techniques have an
established role in treatment of chronic pain and related
conditions. A few non pharmacological techniques have been
employed to avoid the adverse effects of drugs. They have also
proven to be cost-effective. Liberal fluid administration is the
most common non pharmacological methodology used for the
prevention of PONV. However, the associated volume overload
can be detrimental
Aim: To compare the efficacy of P6 acupoint stimulation,
ondansetron and dexamethasone in the prevention of PONV in
laparoscopic surgeries.
Materials and Methods: This was a randomised clinical study,
conducted in the Department of Anaesthesiology at a Tertiary
Care Medical College and Hospital, India. The duration of the
study was five months, from June 2022 to October 2022. A
total of 120 patients posted for laparoscopic surgeries were
divided randomly into three groups, group A, group O and
group D. Patients were allocated by computer-generated
randomisation. Patients in group A received capsicum plaster
at P6 point. Patients in group O received 4 mg of ondansetron
and patients of group D received 8 mg of dexamethasone.
They were given 30 minutes before induction. Postoperatively,
patients were extubated and shifted to postanaesthesia care
unit for further monitoring. The demographic data, baseline
vitals, surgical procedure, duration of surgery and duration of
Carbon Dioxide (CO2
) insufflation were noted intraoperatively.
Additional fentanyl requirement, total analgesic requirement,
postoperative heart rate, Mean Arterial Pressure (MAP), the
incidence of PONV, nausea and vomiting score, number of
episodes the requirement of rescue antiemetic, postoperative
complication, adverse reactions and patient satisfaction score
were all recorded postoperatively and was compared between
the three groups using one-way Analysis of Variance (ANOVA).
The data was analysed using Statistical Package for Social
Sciences (SPSS) version 21.0.
Results: The mean age of the study participants for group
A was 40.42±11.05 years, group O was 40.92±10.49 years
and group D was 40.30±10.01 years, respectively. The three
groups were comparable with respect to the demographics,
baseline vitals, surgical procedure, duration of surgery, duration
of CO2
insufflation, additional fentanyl requirement, total
analgesic requirement, postoperative heart rate, and MAP. The
incidence of PONV was insignificant between the groups with
p-value=0.866. The p-value of nausea and vomiting scores were
insignificant. The number of episodes of nausea and vomiting
was also comparable between the groups p-value=0.880 and
0.375, respectively. The requirement of rescue antiemetic
vomiting was insignificant with p-value=0.810.
Conclusion: Ondansetron, dexamethasone and P6
acupoint stimulation are equally effective as prophylaxis
for the management of PONV. It can be concluded that, P6
acustimulation can be used as an alternative to pharmacological
agents for the management of PONV. |
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| ISSN: | 2249-782X 0973-709X |