THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus)
The investigation of the effects of a-chlorohydrin on the gestation of the wistar rat has been carried out to determine whether a-chlorohydrin could interfere with the gestation of the rat and gestation period for optimal sensitivity. Alpha-chlorohydrin was administered by gavage to three differe...
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| Format: | Article |
| Language: | English |
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SEAMEO, BIOTROP
2011-11-01
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| Series: | Biotropia: The Southeast Asian Journal of Tropical Biology |
| Online Access: | https://journal.biotrop.org/index.php/biotropia/article/view/145 |
| _version_ | 1797758554503905280 |
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| author | RAHMANIAH RAHMANIAH |
| author_facet | RAHMANIAH RAHMANIAH |
| author_sort | RAHMANIAH RAHMANIAH |
| collection | DOAJ |
| description | The investigation of the effects of a-chlorohydrin on the gestation of the wistar rat has been
carried out to determine whether a-chlorohydrin could interfere with the gestation of the rat and
gestation period for optimal sensitivity. Alpha-chlorohydrin was administered by gavage to three
different groups of pregnant rats, namely on the first (pre-implantation period), sixth (early post-
implantation period) or fourteenth (late post-implantation period) gestation day, at a single dose of 62.5; 75
and 90 mg/kg body weight. Rats were sacrificed on the IS* gestation day. Number of implantations,
gestation loss and post-implantation mortality were recorded. The results revealed that 75 and 90 mg/kg
body weight of a-chlorohydrin significantly interfered with all the gestation periods used. For the pre-
implantation group, a-chlorohydrin decreased significantly the implantation number, but increased the
gestation loss as well as the post-implantation mortality compared to the control groups. For the early
post-implantation and late post-implantation groups, a-chlorohydrin caused a significant increase in
post-implantation mortality compared to the control groups. From these results it is concluded that a-
chlorohydrin at 75 and 90 mg/kg body weight influences the gestation of the wistar rat administered
during the pre-implantation period as the most sensitive gestation period.
Key words : a-chlorohydrin//tattu? norvegi'ctu/rat/pre-implantation/early post-implantation/late post-
implantation/implantation/gestation loss/post-implantation mortality. |
| first_indexed | 2024-03-12T18:31:39Z |
| format | Article |
| id | doaj.art-239aade1e2604dec9e58a78278753799 |
| institution | Directory Open Access Journal |
| issn | 0215-6334 1907-770X |
| language | English |
| last_indexed | 2024-03-12T18:31:39Z |
| publishDate | 2011-11-01 |
| publisher | SEAMEO, BIOTROP |
| record_format | Article |
| series | Biotropia: The Southeast Asian Journal of Tropical Biology |
| spelling | doaj.art-239aade1e2604dec9e58a782787537992023-08-02T08:16:35ZengSEAMEO, BIOTROPBiotropia: The Southeast Asian Journal of Tropical Biology0215-63341907-770X2011-11-011210.11598/btb.1999.0.12.145THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus)RAHMANIAH RAHMANIAH0Department of Biology, University ofHaluoleoThe investigation of the effects of a-chlorohydrin on the gestation of the wistar rat has been carried out to determine whether a-chlorohydrin could interfere with the gestation of the rat and gestation period for optimal sensitivity. Alpha-chlorohydrin was administered by gavage to three different groups of pregnant rats, namely on the first (pre-implantation period), sixth (early post- implantation period) or fourteenth (late post-implantation period) gestation day, at a single dose of 62.5; 75 and 90 mg/kg body weight. Rats were sacrificed on the IS* gestation day. Number of implantations, gestation loss and post-implantation mortality were recorded. The results revealed that 75 and 90 mg/kg body weight of a-chlorohydrin significantly interfered with all the gestation periods used. For the pre- implantation group, a-chlorohydrin decreased significantly the implantation number, but increased the gestation loss as well as the post-implantation mortality compared to the control groups. For the early post-implantation and late post-implantation groups, a-chlorohydrin caused a significant increase in post-implantation mortality compared to the control groups. From these results it is concluded that a- chlorohydrin at 75 and 90 mg/kg body weight influences the gestation of the wistar rat administered during the pre-implantation period as the most sensitive gestation period. Key words : a-chlorohydrin//tattu? norvegi'ctu/rat/pre-implantation/early post-implantation/late post- implantation/implantation/gestation loss/post-implantation mortality.https://journal.biotrop.org/index.php/biotropia/article/view/145 |
| spellingShingle | RAHMANIAH RAHMANIAH THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus) Biotropia: The Southeast Asian Journal of Tropical Biology |
| title | THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus) |
| title_full | THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus) |
| title_fullStr | THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus) |
| title_full_unstemmed | THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus) |
| title_short | THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus) |
| title_sort | effects of a chlorohydrin on the gestation of the wistar rat rattus norvegicus |
| url | https://journal.biotrop.org/index.php/biotropia/article/view/145 |
| work_keys_str_mv | AT rahmaniahrahmaniah theeffectsofachlorohydrinonthegestationofthewistarratrattusnorvegicus AT rahmaniahrahmaniah effectsofachlorohydrinonthegestationofthewistarratrattusnorvegicus |