Diesel Exhaust Particulates Enhances Susceptibility of LPS-Induced Acute Lung Injury through Upregulation of the IL-17 Cytokine-Derived TGF-β<sub>1</sub>/Collagen I Expression and Activation of NLRP3 Inflammasome Signaling in Mice

Diesel Exhaust Particulates Enhances Susceptibility of LPS-Induced Acute Lung Injury through Upregulation of the IL-17 Cytokine-Derived TGF-β<sub>1</sub>/Collagen I Expression and Activation of NLRP3 Inflammasome Signaling in Mice

Diesel exhaust particulates (DEP) adversely affect the respiratory system and exacerbate lung diseases, resulting in high mortality rates. However, its pathogenesis is complicated, and the mechanisms involved are incompletely understood. We investigated the effects of DEP pre-exposure on lipopolysac...

Full description

Bibliographic Details
Main Authors: Dong Im Kim, Mi-Kyung Song, Kyuhong Lee
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomolecules
Subjects:
diesel exhaust particulate
acute lung injury
lung fibrosis
NLRP3
IL-17
TGF-β<sub>1</sub>
Online Access:https://www.mdpi.com/2218-273X/11/1/67

Similar Items

Similar Items