CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue

CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue

Cytotoxic T lymphocyte antigen-2 (CTLA-2) alpha has been reported to suppress the activities of cathepsin L (Cath L), which is deeply involved in angiogenesis. Therefore, we assessed whether CTLA-2 alpha plays a role in angiogenesis in ocular tissue. To establish models of corneal inflammation and e...

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Bibliographic Details
Main Authors: Kazuichi Maruyama, Kazuhito Yoneda, Sunao Sugita, Yoshimi Yamamoto, Masato Koike, Christoph Peters, Yasuo Uchiyama, Kohji Nishida
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
corneal inflammation
choroidal neovascularization
cytotoxic T lymphocyte antigen-2 alpha
angiogenesis
Online Access:https://www.mdpi.com/2076-3921/10/3/456

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