Activation of the insulin receptor by insulin-like growth factor 2

Activation of the insulin receptor by insulin-like growth factor 2

Abstract Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has different binding properties on two IR isoforms, mimicking insulin’s function. However, the molecular mechanism underlying IGF2-induced IR activation remains unclear. Here, we present cryo-EM struc...

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Bibliographic Details
Main Authors: Weidong An, Catherine Hall, Jie Li, Albert Hung, Jiayi Wu, Junhee Park, Liwei Wang, Xiao-chen Bai, Eunhee Choi
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46990-6

Internet

https://doi.org/10.1038/s41467-024-46990-6

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