Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous condition that affects women of reproductive age. The association between PCOS and cardiovascular risk according to body mass index (BMI) categories is unclear.ObjectiveWe evaluated the association between cardiovascular risk according to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.822079/full |
| _version_ | 1797799475237879808 |
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| author | Chenchen Zhuang Xufei Luo Wenjuan Wang Runmin Sun Miaomiao Qi Jing Yu |
| author_facet | Chenchen Zhuang Xufei Luo Wenjuan Wang Runmin Sun Miaomiao Qi Jing Yu |
| author_sort | Chenchen Zhuang |
| collection | DOAJ |
| description | BackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous condition that affects women of reproductive age. The association between PCOS and cardiovascular risk according to body mass index (BMI) categories is unclear.ObjectiveWe evaluated the association between cardiovascular risk according to BMI categories and PCOS in women of reproductive age.MethodsA literature search was conducted in the EMBASE, MEDLINE, Cochrane Library, and PubMed databases from their inception to 9 September, 2021. Observational cross-sectional, retrospective, and prospective controlled studies were included. The main analyses examined the relationship between cardiovascular risks (i.e., blood pressure and lipid levels) and BMI in women of reproductive age with PCOS.ResultsThirty-eight studies, with a total of 6,078 subjects, were included in this metaanalysis. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were higher in women of reproductive age with PCOS. Lower high-density lipoprotein (HDL)-cholesterol [SMD (95% CI): −0.21 (−0.35, −0.08), p = 0.002], higher triglycerides [SMD (95% CI): 0.38 (0.29, 0.48), p < 0.001], higher low-density lipoprotein (LDL)-cholesterol [SMD (95% CI): 0.29 (0.20, 0.39), p < 0.001], higher nonHDL-cholesterol [SMD (95% CI): 0.42 (0.31, 0.52), p < 0.001] and waist-to-hip ratio (WHR) [MD (95% CI): 0.03 (0.02, 0.04), p < 0.001] were seen in women of reproductive age with PCOS. In addition, the subgroup analysis revealed that systolic BP and HDL-cholesterol increased at BMI < 25 kg/m2 and BMI 25–30 kg/m2. Diastolic BP increased at BMI 25–30 kg/m2. Triglycerides, LDL-cholesterol, nonHDL-cholesterol, and WHR increased in all BMI categories.ConclusionsPCOS is associated with cardiovascular risk. Lipid levels and BP increased in women of reproductive age with PCOS, regardless of BMI.Systematic Review RegistrationOpen Science Framework (10.17605/OSF.IO/92NBY). |
| first_indexed | 2024-03-13T04:19:29Z |
| format | Article |
| id | doaj.art-239d6a970c034acab5361cbc73257121 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T04:19:29Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-239d6a970c034acab5361cbc732571212023-06-20T12:04:40ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-02-01910.3389/fcvm.2022.822079822079Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-AnalysisChenchen Zhuang0Xufei Luo1Wenjuan Wang2Runmin Sun3Miaomiao Qi4Jing Yu5Hypertension Center, Lanzhou University Second Hospital, Lanzhou, ChinaSchool of Public Health, Lanzhou University, Lanzhou, ChinaHypertension Center, Lanzhou University Second Hospital, Lanzhou, ChinaHypertension Center, Lanzhou University Second Hospital, Lanzhou, ChinaHypertension Center, Lanzhou University Second Hospital, Lanzhou, ChinaHypertension Center, Lanzhou University Second Hospital, Lanzhou, ChinaBackgroundPolycystic ovary syndrome (PCOS) is a heterogeneous condition that affects women of reproductive age. The association between PCOS and cardiovascular risk according to body mass index (BMI) categories is unclear.ObjectiveWe evaluated the association between cardiovascular risk according to BMI categories and PCOS in women of reproductive age.MethodsA literature search was conducted in the EMBASE, MEDLINE, Cochrane Library, and PubMed databases from their inception to 9 September, 2021. Observational cross-sectional, retrospective, and prospective controlled studies were included. The main analyses examined the relationship between cardiovascular risks (i.e., blood pressure and lipid levels) and BMI in women of reproductive age with PCOS.ResultsThirty-eight studies, with a total of 6,078 subjects, were included in this metaanalysis. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were higher in women of reproductive age with PCOS. Lower high-density lipoprotein (HDL)-cholesterol [SMD (95% CI): −0.21 (−0.35, −0.08), p = 0.002], higher triglycerides [SMD (95% CI): 0.38 (0.29, 0.48), p < 0.001], higher low-density lipoprotein (LDL)-cholesterol [SMD (95% CI): 0.29 (0.20, 0.39), p < 0.001], higher nonHDL-cholesterol [SMD (95% CI): 0.42 (0.31, 0.52), p < 0.001] and waist-to-hip ratio (WHR) [MD (95% CI): 0.03 (0.02, 0.04), p < 0.001] were seen in women of reproductive age with PCOS. In addition, the subgroup analysis revealed that systolic BP and HDL-cholesterol increased at BMI < 25 kg/m2 and BMI 25–30 kg/m2. Diastolic BP increased at BMI 25–30 kg/m2. Triglycerides, LDL-cholesterol, nonHDL-cholesterol, and WHR increased in all BMI categories.ConclusionsPCOS is associated with cardiovascular risk. Lipid levels and BP increased in women of reproductive age with PCOS, regardless of BMI.Systematic Review RegistrationOpen Science Framework (10.17605/OSF.IO/92NBY).https://www.frontiersin.org/articles/10.3389/fcvm.2022.822079/fullpolycystic ovary syndromecardiovascular riskreproductive-agemeta-analysisbody mass index |
| spellingShingle | Chenchen Zhuang Xufei Luo Wenjuan Wang Runmin Sun Miaomiao Qi Jing Yu Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Frontiers in Cardiovascular Medicine polycystic ovary syndrome cardiovascular risk reproductive-age meta-analysis body mass index |
| title | Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis |
| title_full | Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis |
| title_fullStr | Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis |
| title_short | Cardiovascular Risk According to Body Mass Index in Women of Reproductive Age With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis |
| title_sort | cardiovascular risk according to body mass index in women of reproductive age with polycystic ovary syndrome a systematic review and meta analysis |
| topic | polycystic ovary syndrome cardiovascular risk reproductive-age meta-analysis body mass index |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.822079/full |
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