Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma

Resibufogenin Targets the ATP1A1 Signaling Cascade to Induce G2/M Phase Arrest and Inhibit Invasion in Glioma

Resibufogenin (RB) is a major active ingredient in the traditional Chinese medicine Chansu and has garnered considerable attention for its efficacy in the treatment of cancer. However, the anticancer effects and underlying mechanisms of RB on glioblastoma (GBM) remain unknown. Here, we found that RB...

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Bibliographic Details
Main Authors: Xun Zhang, Zhong Yao, Zhiyi Xue, Shuai Wang, Xuemeng Liu, Yaotian Hu, Yan Zhang, Jian Wang, Xingang Li, Anjing Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
resibufogenin
GBM
proliferation
invasion
ATP1A1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.855626/full

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