Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity

Effects of natural mutations in lecithin:cholesterol acyltransferase on the enzyme structure and activity

A molecular model was built for human lecithin:cholesterol acyltransferase (LCAT) based upon the structural homology between this enzyme and lipases (Peelman et al. 1998. Prot. Sci. 7: 585–597). We proposed that LCAT belongs to the α/β hydrolase fold family, and that the central domain of LCAT consi...

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Bibliographic Details
Main Authors:	F. Peelman, J-L. Verschelde, B. Vanloo, C. Ampe, C. Labeur, J. Tavernier, J. Vandekerckhove, M. Rosseneu
Format:	Article
Language:	English
Published:	Elsevier 1999-01-01
Series:	Journal of Lipid Research
Subjects:	lecithin:cholesterol acyltransferase mutants enzymatic activity structure lipoproteins reverse cholesterol transport
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520333393

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