AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study
Abstract Background AB0 blood groups and Rhesus factor expression have been associated with carcinogenesis, response to treatment and tumor progression in several malignancies. The aim of the present study was to test the hypothesis that AB0 blood groups and Rhesus factor expression are associated w...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4289-6 |
| _version_ | 1819275024256729088 |
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| author | Veronika Seebacher Stephan Polterauer Alexander Reinthaller Heinz Koelbl Regina Achleitner Astrid Berger Nicole Concin |
| author_facet | Veronika Seebacher Stephan Polterauer Alexander Reinthaller Heinz Koelbl Regina Achleitner Astrid Berger Nicole Concin |
| author_sort | Veronika Seebacher |
| collection | DOAJ |
| description | Abstract Background AB0 blood groups and Rhesus factor expression have been associated with carcinogenesis, response to treatment and tumor progression in several malignancies. The aim of the present study was to test the hypothesis that AB0 blood groups and Rhesus factor expression are associated with clinical outcome in patients with epithelial ovarian cancer (EOC). Methods AB0 blood groups and Rhesus factor expression were evaluated in a retrospective multicenter study including 518 patients with EOC. Their association with patients’ survival was assessed using univariate and multivariable analyses. Results Neither AB0 blood groups nor Rhesus factor expression were associated with clinico-pathological parameters, recurrence-free, cancer-specific, or overall survival. In a subgroup of patients with high-grade serous adenocarcinoma, however, blood groups B and AB were associated with a better 5-year cancer-specific survival rate compared to blood groups A and 0 (60.3 ± 8.6% vs. 43.8 ± 3.6%, p = 0.04). Yet, this was not significant in multivariable analysis. Conclusions AB0 blood groups and Rhesus factor expression are both neither associated with features of biologically aggressive disease nor clinical outcome in patients with EOC. Further investigation of the role of the blood group B antigen on cancer-specific survival in the subgroup of high-grade serous should be considered. |
| first_indexed | 2024-12-23T23:17:45Z |
| format | Article |
| id | doaj.art-23a1e5f773d4482faa4697b9e7d2523f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-23T23:17:45Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-23a1e5f773d4482faa4697b9e7d2523f2022-12-21T17:26:27ZengBMCBMC Cancer1471-24072018-04-011811710.1186/s12885-018-4289-6AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre studyVeronika Seebacher0Stephan Polterauer1Alexander Reinthaller2Heinz Koelbl3Regina Achleitner4Astrid Berger5Nicole Concin6Department of Gynecology and Gynecologic Oncology, Comprehensive Cancer Center Vienna, Gynecologic Cancer Unit, Medical University of ViennaDepartment of Gynecology and Gynecologic Oncology, Comprehensive Cancer Center Vienna, Gynecologic Cancer Unit, Medical University of ViennaDepartment of Gynecology and Gynecologic Oncology, Comprehensive Cancer Center Vienna, Gynecologic Cancer Unit, Medical University of ViennaDepartment of Gynecology and Gynecologic Oncology, Comprehensive Cancer Center Vienna, Gynecologic Cancer Unit, Medical University of ViennaDepartment of Gynaecology and Obstetrics, Medical University of InnsbruckDepartment of Gynaecology and Obstetrics, Medical University of InnsbruckDepartment of Gynaecology and Obstetrics, Medical University of InnsbruckAbstract Background AB0 blood groups and Rhesus factor expression have been associated with carcinogenesis, response to treatment and tumor progression in several malignancies. The aim of the present study was to test the hypothesis that AB0 blood groups and Rhesus factor expression are associated with clinical outcome in patients with epithelial ovarian cancer (EOC). Methods AB0 blood groups and Rhesus factor expression were evaluated in a retrospective multicenter study including 518 patients with EOC. Their association with patients’ survival was assessed using univariate and multivariable analyses. Results Neither AB0 blood groups nor Rhesus factor expression were associated with clinico-pathological parameters, recurrence-free, cancer-specific, or overall survival. In a subgroup of patients with high-grade serous adenocarcinoma, however, blood groups B and AB were associated with a better 5-year cancer-specific survival rate compared to blood groups A and 0 (60.3 ± 8.6% vs. 43.8 ± 3.6%, p = 0.04). Yet, this was not significant in multivariable analysis. Conclusions AB0 blood groups and Rhesus factor expression are both neither associated with features of biologically aggressive disease nor clinical outcome in patients with EOC. Further investigation of the role of the blood group B antigen on cancer-specific survival in the subgroup of high-grade serous should be considered.http://link.springer.com/article/10.1186/s12885-018-4289-6Ovarian cancerAB0 blood groupsRhesus factorPrognosisSurvivalOutcome |
| spellingShingle | Veronika Seebacher Stephan Polterauer Alexander Reinthaller Heinz Koelbl Regina Achleitner Astrid Berger Nicole Concin AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study BMC Cancer Ovarian cancer AB0 blood groups Rhesus factor Prognosis Survival Outcome |
| title | AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study |
| title_full | AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study |
| title_fullStr | AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study |
| title_full_unstemmed | AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study |
| title_short | AB0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer – a retrospective multi-centre study |
| title_sort | ab0 blood groups and rhesus factor expression as prognostic parameters in patients with epithelial ovarian cancer a retrospective multi centre study |
| topic | Ovarian cancer AB0 blood groups Rhesus factor Prognosis Survival Outcome |
| url | http://link.springer.com/article/10.1186/s12885-018-4289-6 |
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