Understanding the Potential and Risk of Bacterial Siderophores in Cancer
Siderophores are iron chelating molecules produced by nearly all organisms, most notably by bacteria, to efficiently sequester the limited iron that is available in the environment. Siderophores are an essential component of mammalian iron homeostasis and the ongoing interspecies competition for iro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.867271/full |
| _version_ | 1818252204559040512 |
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| author | Valentina Pita-Grisanti Valentina Pita-Grisanti Valentina Pita-Grisanti Kaylin Chasser Kaylin Chasser Trevor Sobol Trevor Sobol Zobeida Cruz-Monserrate Zobeida Cruz-Monserrate |
| author_facet | Valentina Pita-Grisanti Valentina Pita-Grisanti Valentina Pita-Grisanti Kaylin Chasser Kaylin Chasser Trevor Sobol Trevor Sobol Zobeida Cruz-Monserrate Zobeida Cruz-Monserrate |
| author_sort | Valentina Pita-Grisanti |
| collection | DOAJ |
| description | Siderophores are iron chelating molecules produced by nearly all organisms, most notably by bacteria, to efficiently sequester the limited iron that is available in the environment. Siderophores are an essential component of mammalian iron homeostasis and the ongoing interspecies competition for iron. Bacteria produce a broad repertoire of siderophores with a canonical role in iron chelation and the capacity to perform versatile functions such as interacting with other microbes and the host immune system. Siderophores are a vast area of untapped potential in the field of cancer research because cancer cells demand increased iron concentrations to sustain rapid proliferation. Studies investigating siderophores as therapeutics in cancer generally focused on the role of a few siderophores as iron chelators; however, these studies are limited and some show conflicting results. Moreover, siderophores are biologically conserved, structurally diverse molecules that perform additional functions related to iron chelation. Siderophores also have a role in inflammation due to their iron acquisition and chelation properties. These diverse functions may contribute to both risks and benefits as therapeutic agents in cancer. The potential of siderophore-mediated iron and bacterial modulation to be used in the treatment of cancer warrants further investigation. This review discusses the wide range of bacterial siderophore functions and their utilization in cancer treatment to further expand their functional relevance in cancer detection and treatment. |
| first_indexed | 2024-12-12T16:20:28Z |
| format | Article |
| id | doaj.art-23a3027d65674b278cdf643ce9cb2b81 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T16:20:28Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-23a3027d65674b278cdf643ce9cb2b812022-12-22T00:18:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.867271867271Understanding the Potential and Risk of Bacterial Siderophores in CancerValentina Pita-Grisanti0Valentina Pita-Grisanti1Valentina Pita-Grisanti2Kaylin Chasser3Kaylin Chasser4Trevor Sobol5Trevor Sobol6Zobeida Cruz-Monserrate7Zobeida Cruz-Monserrate8The Ohio State University Interdisciplinary Nutrition Program, The Ohio State University, Columbus, OH, United StatesDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesThe Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, United StatesDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesThe Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, United StatesDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesThe Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, United StatesDivision of Gastroenterology, Hepatology, and Nutrition, Division of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesThe Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, United StatesSiderophores are iron chelating molecules produced by nearly all organisms, most notably by bacteria, to efficiently sequester the limited iron that is available in the environment. Siderophores are an essential component of mammalian iron homeostasis and the ongoing interspecies competition for iron. Bacteria produce a broad repertoire of siderophores with a canonical role in iron chelation and the capacity to perform versatile functions such as interacting with other microbes and the host immune system. Siderophores are a vast area of untapped potential in the field of cancer research because cancer cells demand increased iron concentrations to sustain rapid proliferation. Studies investigating siderophores as therapeutics in cancer generally focused on the role of a few siderophores as iron chelators; however, these studies are limited and some show conflicting results. Moreover, siderophores are biologically conserved, structurally diverse molecules that perform additional functions related to iron chelation. Siderophores also have a role in inflammation due to their iron acquisition and chelation properties. These diverse functions may contribute to both risks and benefits as therapeutic agents in cancer. The potential of siderophore-mediated iron and bacterial modulation to be used in the treatment of cancer warrants further investigation. This review discusses the wide range of bacterial siderophore functions and their utilization in cancer treatment to further expand their functional relevance in cancer detection and treatment.https://www.frontiersin.org/articles/10.3389/fonc.2022.867271/fullmicrobiomebacteriasiderophoresenterobactindeferoxaminecancer |
| spellingShingle | Valentina Pita-Grisanti Valentina Pita-Grisanti Valentina Pita-Grisanti Kaylin Chasser Kaylin Chasser Trevor Sobol Trevor Sobol Zobeida Cruz-Monserrate Zobeida Cruz-Monserrate Understanding the Potential and Risk of Bacterial Siderophores in Cancer Frontiers in Oncology microbiome bacteria siderophores enterobactin deferoxamine cancer |
| title | Understanding the Potential and Risk of Bacterial Siderophores in Cancer |
| title_full | Understanding the Potential and Risk of Bacterial Siderophores in Cancer |
| title_fullStr | Understanding the Potential and Risk of Bacterial Siderophores in Cancer |
| title_full_unstemmed | Understanding the Potential and Risk of Bacterial Siderophores in Cancer |
| title_short | Understanding the Potential and Risk of Bacterial Siderophores in Cancer |
| title_sort | understanding the potential and risk of bacterial siderophores in cancer |
| topic | microbiome bacteria siderophores enterobactin deferoxamine cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.867271/full |
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