Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial
Polyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are synthesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate) [(P(3HB-<i>co</i>-4HB)] emerge...
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MDPI AG
2020-12-01
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author | Jun Meng Chai Tan Suet May Amelia Govindan Kothandaraman Mouriya Kesaven Bhubalan Al-Ashraf Abdullah Amirul Sevakumaran Vigneswari Seeram Ramakrishna |
author_facet | Jun Meng Chai Tan Suet May Amelia Govindan Kothandaraman Mouriya Kesaven Bhubalan Al-Ashraf Abdullah Amirul Sevakumaran Vigneswari Seeram Ramakrishna |
author_sort | Jun Meng Chai |
collection | DOAJ |
description | Polyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are synthesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate) [(P(3HB-<i>co</i>-4HB)] emerges as an attractive biomaterial to be applied in medical applications owing to its desirable mechanical and physical properties, non-genotoxicity and biocompatibility eliciting appropriate host tissue responses. The tailorable physical and chemical properties and easy surface functionalisation of P(3HB-<i>co</i>-4HB) increase its practicality to be developed as functional medical substitutes. However, its applicability is sometimes limited due to its hydrophobic nature due to fewer bio-recognition sites. In this review, we demonstrate how surface modifications of PHAs, mainly P(3HB-<i>co</i>-4HB), will overcome these limitations and facilitate their use in diverse medical applications. The integration of nanotechnology has drastically enhanced the functionality of P(3HB-<i>co</i>-4HB) biomaterials for application in complex biological environments of the human body. The design of versatile P(3HB-<i>co</i>-4HB) materials with surface modifications promise a non-cytotoxic and biocompatible material without inducing severe inflammatory responses for enhanced effective alternatives in healthcare biotechnology. The enticing work carried out with P(3HB-<i>co</i>-4HB) promises to be one of the next-generation materials in biomedicines which will facilitate translation into the clinic in the future. |
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issn | 2073-4360 |
language | English |
last_indexed | 2024-03-10T13:46:14Z |
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publisher | MDPI AG |
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series | Polymers |
spelling | doaj.art-23a5aefbcd364a1fbc30d615de37bda32023-11-21T02:33:29ZengMDPI AGPolymers2073-43602020-12-011315110.3390/polym13010051Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation BiomaterialJun Meng Chai0Tan Suet May Amelia1Govindan Kothandaraman Mouriya2Kesaven Bhubalan3Al-Ashraf Abdullah Amirul4Sevakumaran Vigneswari5Seeram Ramakrishna6Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, MalaysiaFaculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, MalaysiaFaculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, MalaysiaFaculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, MalaysiaSchool of Biological Sciences, Universiti Sains Malaysia, Penang 11800, MalaysiaFaculty of Science and Marine Environment, Universiti Malaysia Terengganu, Kuala Nerus 21030, Terengganu, MalaysiaCenter for Nanofibers and Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore 117581, SingaporePolyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are synthesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate) [(P(3HB-<i>co</i>-4HB)] emerges as an attractive biomaterial to be applied in medical applications owing to its desirable mechanical and physical properties, non-genotoxicity and biocompatibility eliciting appropriate host tissue responses. The tailorable physical and chemical properties and easy surface functionalisation of P(3HB-<i>co</i>-4HB) increase its practicality to be developed as functional medical substitutes. However, its applicability is sometimes limited due to its hydrophobic nature due to fewer bio-recognition sites. In this review, we demonstrate how surface modifications of PHAs, mainly P(3HB-<i>co</i>-4HB), will overcome these limitations and facilitate their use in diverse medical applications. The integration of nanotechnology has drastically enhanced the functionality of P(3HB-<i>co</i>-4HB) biomaterials for application in complex biological environments of the human body. The design of versatile P(3HB-<i>co</i>-4HB) materials with surface modifications promise a non-cytotoxic and biocompatible material without inducing severe inflammatory responses for enhanced effective alternatives in healthcare biotechnology. The enticing work carried out with P(3HB-<i>co</i>-4HB) promises to be one of the next-generation materials in biomedicines which will facilitate translation into the clinic in the future.https://www.mdpi.com/2073-4360/13/1/51surface modificationspolyhydroxyalkanoatespoly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate)biomedical applicationstissue engineeringbiocompatible |
spellingShingle | Jun Meng Chai Tan Suet May Amelia Govindan Kothandaraman Mouriya Kesaven Bhubalan Al-Ashraf Abdullah Amirul Sevakumaran Vigneswari Seeram Ramakrishna Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial Polymers surface modifications polyhydroxyalkanoates poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate) biomedical applications tissue engineering biocompatible |
title | Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial |
title_full | Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial |
title_fullStr | Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial |
title_full_unstemmed | Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial |
title_short | Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial |
title_sort | surface modified highly biocompatible bacterial poly 3 hydroxybutyrate i co i 4 hydroxybutyrate a review on the promising next generation biomaterial |
topic | surface modifications polyhydroxyalkanoates poly(3-hydroxybutyrate-<i>co</i>-4-hydroxybutyrate) biomedical applications tissue engineering biocompatible |
url | https://www.mdpi.com/2073-4360/13/1/51 |
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