Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens
Foodborne infection is one of the leading sources of infections spreading across the world. Foodborne pathogens are recognized as multidrug-resistant (MDR) pathogens posing a significant problem in the food industry and healthy consumers resulting in enhanced economic burden, and nosocomial infectio...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422000898 |
| _version_ | 1818172672809369600 |
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| author | Rahul Bhattacharjee Aditya Nandi Priya Mitra Koustav Saha Paritosh Patel Ealisha Jha Pritam Kumar Panda Sushil Kumar Singh Ateet Dutt Yogendra Kumar Mishra Suresh K. Verma Mrutyunjay Suar |
| author_facet | Rahul Bhattacharjee Aditya Nandi Priya Mitra Koustav Saha Paritosh Patel Ealisha Jha Pritam Kumar Panda Sushil Kumar Singh Ateet Dutt Yogendra Kumar Mishra Suresh K. Verma Mrutyunjay Suar |
| author_sort | Rahul Bhattacharjee |
| collection | DOAJ |
| description | Foodborne infection is one of the leading sources of infections spreading across the world. Foodborne pathogens are recognized as multidrug-resistant (MDR) pathogens posing a significant problem in the food industry and healthy consumers resulting in enhanced economic burden, and nosocomial infections. The continued search for enhanced microbial detection tools has piqued the interest of the CRISPR-Cas system and Nanoparticles. CRISPR-Cas system is present in the bacterial genome of some prokaryotes and is repurposed as a theragnostic tool against MDR pathogens. Nanoparticles and composites have also emerged as an efficient tool in theragnostic applications against MDR pathogens. The diagnostic limitations of the CRISPR-Cas system are believed to be overcome by a synergistic combination of the nanoparticles system and CRISPR-Cas using nanoparticles as vehicles. In this review, we have discussed the diagnostic application of CRISPR-Cas technologies along with their potential usage in applications like phage resistance, phage vaccination, strain typing, genome editing, and antimicrobial. we have also elucidated the antimicrobial and detection role of nanoparticles against foodborne MDR pathogens. Moreover, the novel combinatorial approach of CRISPR-Cas and nanoparticles for their synergistic effects in pathogen clearance and drug delivery vehicles has also been discussed. |
| first_indexed | 2024-12-11T19:16:20Z |
| format | Article |
| id | doaj.art-23a5e16d413848d2826cc329d4ab73b0 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-12-11T19:16:20Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-23a5e16d413848d2826cc329d4ab73b02022-12-22T00:53:38ZengElsevierMaterials Today Bio2590-00642022-06-0115100291Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogensRahul Bhattacharjee0Aditya Nandi1Priya Mitra2Koustav Saha3Paritosh Patel4Ealisha Jha5Pritam Kumar Panda6Sushil Kumar Singh7Ateet Dutt8Yogendra Kumar Mishra9Suresh K. Verma10Mrutyunjay Suar11KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaCondensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, SE-751 20, Uppsala, Sweden; Corresponding author.DBT- NECAB, Department of Agricultural Biotechnology, Assam Agriculture University, Jorhat, 785013, Assam, IndiaInstituto de Investigaciones en Materiales, UNAM, CDMX, MexicoMads Clausen Institute, NanoSYD, University of Southern Denmark, Alsion 2, DK-6400, Sønderborg, Denmark; Corresponding author.KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India; Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, SE-751 20, Uppsala, Sweden; Corresponding author. KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India.KIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, India; Corresponding author.Foodborne infection is one of the leading sources of infections spreading across the world. Foodborne pathogens are recognized as multidrug-resistant (MDR) pathogens posing a significant problem in the food industry and healthy consumers resulting in enhanced economic burden, and nosocomial infections. The continued search for enhanced microbial detection tools has piqued the interest of the CRISPR-Cas system and Nanoparticles. CRISPR-Cas system is present in the bacterial genome of some prokaryotes and is repurposed as a theragnostic tool against MDR pathogens. Nanoparticles and composites have also emerged as an efficient tool in theragnostic applications against MDR pathogens. The diagnostic limitations of the CRISPR-Cas system are believed to be overcome by a synergistic combination of the nanoparticles system and CRISPR-Cas using nanoparticles as vehicles. In this review, we have discussed the diagnostic application of CRISPR-Cas technologies along with their potential usage in applications like phage resistance, phage vaccination, strain typing, genome editing, and antimicrobial. we have also elucidated the antimicrobial and detection role of nanoparticles against foodborne MDR pathogens. Moreover, the novel combinatorial approach of CRISPR-Cas and nanoparticles for their synergistic effects in pathogen clearance and drug delivery vehicles has also been discussed.http://www.sciencedirect.com/science/article/pii/S2590006422000898Antimicrobial activityDiagnosisCRISPR-Cas systemNanoparticle and MDR food-Borne- pathogens |
| spellingShingle | Rahul Bhattacharjee Aditya Nandi Priya Mitra Koustav Saha Paritosh Patel Ealisha Jha Pritam Kumar Panda Sushil Kumar Singh Ateet Dutt Yogendra Kumar Mishra Suresh K. Verma Mrutyunjay Suar Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens Materials Today Bio Antimicrobial activity Diagnosis CRISPR-Cas system Nanoparticle and MDR food-Borne- pathogens |
| title | Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens |
| title_full | Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens |
| title_fullStr | Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens |
| title_full_unstemmed | Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens |
| title_short | Theragnostic application of nanoparticle and CRISPR against food-borne multi-drug resistant pathogens |
| title_sort | theragnostic application of nanoparticle and crispr against food borne multi drug resistant pathogens |
| topic | Antimicrobial activity Diagnosis CRISPR-Cas system Nanoparticle and MDR food-Borne- pathogens |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422000898 |
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