Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up
Background. Acute coronary syndrome (ACS) causes pathophysiological changes in exercise capacity, N-terminal part of pro-brain natriuretic peptide (NT-proBNP), and adiponectin that impact the course of coronary artery disease and clinical outcomes after cardiac rehabilitation (CR). However, the seri...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2022-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/6538296 |
| _version_ | 1798024251088830464 |
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| author | Hong Jin Yuefei Liu Bernd Schweikert Harry Hahman Lei Wang Armin Imhof Rainer Muche Wolfgang König Jürgen M. Steinacker |
| author_facet | Hong Jin Yuefei Liu Bernd Schweikert Harry Hahman Lei Wang Armin Imhof Rainer Muche Wolfgang König Jürgen M. Steinacker |
| author_sort | Hong Jin |
| collection | DOAJ |
| description | Background. Acute coronary syndrome (ACS) causes pathophysiological changes in exercise capacity, N-terminal part of pro-brain natriuretic peptide (NT-proBNP), and adiponectin that impact the course of coronary artery disease and clinical outcomes after cardiac rehabilitation (CR). However, the serial changes and the relationship between the changes in these parameters for a prolonged term remain uninvestigated. Methods. Eighty-one patients with ACS underwent a three- or four-week CR program after acute care and were followed up for 12 months. Exercise capacity on a cycle ergometer and blood levels of NT-proBNP and adiponectin were determined before and after CR as well as at the 12-month follow-up. Results. Exercise capacity increased from 100 watts (in median) before CR to 138 watts after CR and 150 watts at 12 months. The NT-proBNP level (526 pg/ml before CR) remained almost unchanged after CR (557 pg/ml) and then decreased at 12 months (173 pg/ml). The adiponectin level (14.5 µg/ml before CR) increased after CR (16.0 µg/ml) and at 12 months (17.2 µg/ml). There was no significant correlation among the changes in these parameters at each observation time point. Conclusion. During the observation period from before CR to the 12-month follow-up, exercise capacity, NT-proBNP, and adiponectin underwent significant changes; however, these changes were independent from each other and not correlated linearly, and they provide complementary information in clinical practice. Thus, all these parameters should be included and determined at different time points for a prolonged period of time. |
| first_indexed | 2024-04-11T17:59:28Z |
| format | Article |
| id | doaj.art-23a6c265bf3f46ddbb554b6dbc63c94c |
| institution | Directory Open Access Journal |
| issn | 2090-0597 |
| language | English |
| last_indexed | 2024-04-11T17:59:28Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj.art-23a6c265bf3f46ddbb554b6dbc63c94c2022-12-22T04:10:33ZengHindawi LimitedCardiology Research and Practice2090-05972022-01-01202210.1155/2022/6538296Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-UpHong Jin0Yuefei Liu1Bernd Schweikert2Harry Hahman3Lei Wang4Armin Imhof5Rainer Muche6Wolfgang König7Jürgen M. Steinacker8Division of Sports and Rehabilitation MedicineDivision of Sports and Rehabilitation MedicineInstitute of Health Economics and Health Care ManagementSchwabenland HospitalDivision of Sports and Rehabilitation MedicineDepartment of CardiologyInstitute of BiometricsDepartment of CardiologyDivision of Sports and Rehabilitation MedicineBackground. Acute coronary syndrome (ACS) causes pathophysiological changes in exercise capacity, N-terminal part of pro-brain natriuretic peptide (NT-proBNP), and adiponectin that impact the course of coronary artery disease and clinical outcomes after cardiac rehabilitation (CR). However, the serial changes and the relationship between the changes in these parameters for a prolonged term remain uninvestigated. Methods. Eighty-one patients with ACS underwent a three- or four-week CR program after acute care and were followed up for 12 months. Exercise capacity on a cycle ergometer and blood levels of NT-proBNP and adiponectin were determined before and after CR as well as at the 12-month follow-up. Results. Exercise capacity increased from 100 watts (in median) before CR to 138 watts after CR and 150 watts at 12 months. The NT-proBNP level (526 pg/ml before CR) remained almost unchanged after CR (557 pg/ml) and then decreased at 12 months (173 pg/ml). The adiponectin level (14.5 µg/ml before CR) increased after CR (16.0 µg/ml) and at 12 months (17.2 µg/ml). There was no significant correlation among the changes in these parameters at each observation time point. Conclusion. During the observation period from before CR to the 12-month follow-up, exercise capacity, NT-proBNP, and adiponectin underwent significant changes; however, these changes were independent from each other and not correlated linearly, and they provide complementary information in clinical practice. Thus, all these parameters should be included and determined at different time points for a prolonged period of time.http://dx.doi.org/10.1155/2022/6538296 |
| spellingShingle | Hong Jin Yuefei Liu Bernd Schweikert Harry Hahman Lei Wang Armin Imhof Rainer Muche Wolfgang König Jürgen M. Steinacker Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up Cardiology Research and Practice |
| title | Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up |
| title_full | Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up |
| title_fullStr | Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up |
| title_full_unstemmed | Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up |
| title_short | Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up |
| title_sort | serial changes in exercise capacity nt probnp and adiponectin in patients with acute coronary syndrome before and after phase ii rehabilitation as well as at the 12 month follow up |
| url | http://dx.doi.org/10.1155/2022/6538296 |
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