The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders
Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/24/5246 |
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| author | Mirjana Nacka-Aleksić Andrea Pirković Aleksandra Vilotić Žanka Bojić-Trbojević Milica Jovanović Krivokuća Francesca Giampieri Maurizio Battino Dragana Dekanski |
| author_facet | Mirjana Nacka-Aleksić Andrea Pirković Aleksandra Vilotić Žanka Bojić-Trbojević Milica Jovanović Krivokuća Francesca Giampieri Maurizio Battino Dragana Dekanski |
| author_sort | Mirjana Nacka-Aleksić |
| collection | DOAJ |
| description | Polyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring. |
| first_indexed | 2024-03-09T16:00:02Z |
| format | Article |
| id | doaj.art-23a72c0abb094d549cac80bcea1b1966 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T16:00:02Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-23a72c0abb094d549cac80bcea1b19662023-11-24T17:07:59ZengMDPI AGNutrients2072-66432022-12-011424524610.3390/nu14245246The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related DisordersMirjana Nacka-Aleksić0Andrea Pirković1Aleksandra Vilotić2Žanka Bojić-Trbojević3Milica Jovanović Krivokuća4Francesca Giampieri5Maurizio Battino6Dragana Dekanski7Institute for the Application of Nuclear Energy, Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, SerbiaInstitute for the Application of Nuclear Energy, Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, SerbiaInstitute for the Application of Nuclear Energy, Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, SerbiaInstitute for the Application of Nuclear Energy, Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, SerbiaInstitute for the Application of Nuclear Energy, Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, SerbiaResearch Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, SpainResearch Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, SpainInstitute for the Application of Nuclear Energy, Department for Biology of Reproduction, University of Belgrade, Banatska 31b, 11080 Belgrade, SerbiaPolyphenols are a group of phytochemicals with extensive biological functions and health-promoting potential. These compounds are present in most foods of plant origin and their increased widespread availability through the intake of nutritional supplements, fortified foods, and beverages, has also led to increased exposure throughout gestation. In this narrative review, we focus on the role of polyphenols in both healthy and pathological pregnancy. General information related to their classification and function is followed by an overview of their known effects in early-pregnancy events, including the current insights into molecular mechanisms involved. Further, we provide an overview of their involvement in some of the most common pregnancy-associated pathological conditions, such as preeclampsia and gestational diabetes mellitus. Additionally, we also discuss the estimated possible risk of polyphenol consumption on pregnancy outcomes. The consumption of dietary polyphenols during pregnancy needs particular attention considering the possible effects of polyphenols on the mechanisms involved in maternal adaptation and fetal development. Further studies are strongly needed to unravel the in vivo effects of polyphenol metabolites during pregnancy, as well as their role on advanced maternal age, prenatal nutrition, and metabolic risk of the offspring.https://www.mdpi.com/2072-6643/14/24/5246polyphenolsearly pregnancytrophoblastgestational diabetes mellituspreeclampsia |
| spellingShingle | Mirjana Nacka-Aleksić Andrea Pirković Aleksandra Vilotić Žanka Bojić-Trbojević Milica Jovanović Krivokuća Francesca Giampieri Maurizio Battino Dragana Dekanski The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders Nutrients polyphenols early pregnancy trophoblast gestational diabetes mellitus preeclampsia |
| title | The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders |
| title_full | The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders |
| title_fullStr | The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders |
| title_full_unstemmed | The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders |
| title_short | The Role of Dietary Polyphenols in Pregnancy and Pregnancy-Related Disorders |
| title_sort | role of dietary polyphenols in pregnancy and pregnancy related disorders |
| topic | polyphenols early pregnancy trophoblast gestational diabetes mellitus preeclampsia |
| url | https://www.mdpi.com/2072-6643/14/24/5246 |
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