Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis
The aim of this study was to compare the estimated blood loss and the frequency of obstetric hemorrhage among pregnant women with and without COVID-19 infection. The study was carried out in the Department of Obstetrics and Gynecology, at the Central Clinical Hospital of the Ministry of the Interior...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/10/2517 |
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| author | Marcin Januszewski Małgorzata Santor-Zaczyńska Laura Ziuzia-Januszewska Michał Kudan Alicja A. Jakimiuk Waldemar Wierzba Artur J. Jakimiuk |
| author_facet | Marcin Januszewski Małgorzata Santor-Zaczyńska Laura Ziuzia-Januszewska Michał Kudan Alicja A. Jakimiuk Waldemar Wierzba Artur J. Jakimiuk |
| author_sort | Marcin Januszewski |
| collection | DOAJ |
| description | The aim of this study was to compare the estimated blood loss and the frequency of obstetric hemorrhage among pregnant women with and without COVID-19 infection. The study was carried out in the Department of Obstetrics and Gynecology, at the Central Clinical Hospital of the Ministry of the Interior and Administration in Warsaw, Poland. From 15 May 2020 to 26 April 2021, a total of 224 parturients with COVID-19 infection were admitted for labor. The control group consisted of 300 randomly recruited pre-pandemic deliveries that took place between 15 May 2019 and 26 April 2020 at the Department. The primary outcome was the presence of postpartum hemorrhage, defined as an estimated blood loss of ≥500 mL within 24 h after birth or the need to transfuse 2 or more units of packed red blood cells (pRBCs). Secondary outcomes were the difference between hemoglobin and hematocrit levels at 24 h postpartum, the number of pRBCs units transfused, and the need for transperitoneal drainage. After applying the propensity-score-matching procedure for postpartum bleeding risk factors, 325 eligible patients were included in the final analysis, divided into 203 COVID-19 positive and 122 COVID-19 negative prepandemic deliveries. SARS-CoV-2 infected patients were characterized by a longer activated partial thromboplastin time (APTT), a reduced prothrombin time (PT), and lower platelet count at initial presentation. COVID-19 deliveries were found to be associated with a higher frequency of postpartum hemorrhage, an increased estimated blood loss, the more frequent use of peritoneal drainage, and more pRBCs units transfused. During the pandemic, an increased risk of postpartum hemorrhage posed another threat to SARS-CoV-2 infected pregnant women. It is essential to be aware of this when approaching COVID-19 delivery and to implement efficient preventative methods. |
| first_indexed | 2024-03-09T20:38:39Z |
| format | Article |
| id | doaj.art-23a95d95cb314fa3be69977011219b7c |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:38:39Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-23a95d95cb314fa3be69977011219b7c2023-11-23T23:04:20ZengMDPI AGBiomedicines2227-90592022-10-011010251710.3390/biomedicines10102517Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched AnalysisMarcin Januszewski0Małgorzata Santor-Zaczyńska1Laura Ziuzia-Januszewska2Michał Kudan3Alicja A. Jakimiuk4Waldemar Wierzba5Artur J. Jakimiuk6Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, PolandDepartment of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, PolandDepartment of Otolaryngology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, PolandDepartment of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, PolandDepartment of Plastic Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, PolandSatellite Campus in Warsaw, University of Humanities and Economics in Lodz, 01-513 Warsaw, PolandDepartment of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, PolandThe aim of this study was to compare the estimated blood loss and the frequency of obstetric hemorrhage among pregnant women with and without COVID-19 infection. The study was carried out in the Department of Obstetrics and Gynecology, at the Central Clinical Hospital of the Ministry of the Interior and Administration in Warsaw, Poland. From 15 May 2020 to 26 April 2021, a total of 224 parturients with COVID-19 infection were admitted for labor. The control group consisted of 300 randomly recruited pre-pandemic deliveries that took place between 15 May 2019 and 26 April 2020 at the Department. The primary outcome was the presence of postpartum hemorrhage, defined as an estimated blood loss of ≥500 mL within 24 h after birth or the need to transfuse 2 or more units of packed red blood cells (pRBCs). Secondary outcomes were the difference between hemoglobin and hematocrit levels at 24 h postpartum, the number of pRBCs units transfused, and the need for transperitoneal drainage. After applying the propensity-score-matching procedure for postpartum bleeding risk factors, 325 eligible patients were included in the final analysis, divided into 203 COVID-19 positive and 122 COVID-19 negative prepandemic deliveries. SARS-CoV-2 infected patients were characterized by a longer activated partial thromboplastin time (APTT), a reduced prothrombin time (PT), and lower platelet count at initial presentation. COVID-19 deliveries were found to be associated with a higher frequency of postpartum hemorrhage, an increased estimated blood loss, the more frequent use of peritoneal drainage, and more pRBCs units transfused. During the pandemic, an increased risk of postpartum hemorrhage posed another threat to SARS-CoV-2 infected pregnant women. It is essential to be aware of this when approaching COVID-19 delivery and to implement efficient preventative methods.https://www.mdpi.com/2227-9059/10/10/2517SARS-CoV-2postpartum hemorrhageCOVID-19obstetriclaborbleeding |
| spellingShingle | Marcin Januszewski Małgorzata Santor-Zaczyńska Laura Ziuzia-Januszewska Michał Kudan Alicja A. Jakimiuk Waldemar Wierzba Artur J. Jakimiuk Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis Biomedicines SARS-CoV-2 postpartum hemorrhage COVID-19 obstetric labor bleeding |
| title | Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis |
| title_full | Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis |
| title_fullStr | Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis |
| title_full_unstemmed | Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis |
| title_short | Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis |
| title_sort | postpartum blood loss in covid 19 patients propensity score matched analysis |
| topic | SARS-CoV-2 postpartum hemorrhage COVID-19 obstetric labor bleeding |
| url | https://www.mdpi.com/2227-9059/10/10/2517 |
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