Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study
Abstract Purpose The aim of this study was to compare intrathecal 1% chloroprocaine with 2% hyperbaric prilocaine in the setting of ambulatory knee arthroscopy. We hypothesized that complete resolution of the sensory block was faster with chloroprocaine. Methods Eighty patients scheduled for knee ar...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Experimental Orthopaedics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40634-021-00332-3 |
| _version_ | 1797321278353309696 |
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| author | E Guntz C Vasseur D Ifrim A Louvard J F Fils Y Kapessidou |
| author_facet | E Guntz C Vasseur D Ifrim A Louvard J F Fils Y Kapessidou |
| author_sort | E Guntz |
| collection | DOAJ |
| description | Abstract Purpose The aim of this study was to compare intrathecal 1% chloroprocaine with 2% hyperbaric prilocaine in the setting of ambulatory knee arthroscopy. We hypothesized that complete resolution of the sensory block was faster with chloroprocaine. Methods Eighty patients scheduled for knee arthroscopy were included in this prospective randomized double‐blind study. Spinal anesthesia was performed with either chloroprocaine (50 mg) or hyperbaric prilocaine (50 mg). Characteristics of sensory and motor blocks and side effects were recorded. Results Mean time to full sensory block recovery was shorter with chloroprocaine (169 (56.1) min vs 248 (59.4)). The characteristics of the sensory blocks were similar at the T12 dermatome level between the two groups. Differences appeared at T10: the percentage of patients with a sensory block was higher, onset quicker and duration longer with hyperbaric prilocaine. The number of patients with a sensory block at T4 dermatome level in both groups was minimal. Times to full motor recovery were identical in both groups (85 (70–99) vs 86 (76–111) min). Time to spontaneous voiding was shorter with chloroprocaine (203 (57.6) min vs 287.3 (47.2) min). Incidence of side effects was low in both groups. Conclusions When considering the characteristics of the sensory block, the use of chloroprocaine may allow an earlier discharge of patients. Cephalic extension was to a higher dermatomal level and the sensory block at T10 level was of prolonged duration with hyperbaric prilocaine, suggesting that the choice between the two drugs should also be performed based on the level of the sensory block requested by the surgery. This study is registered in the US National Clinical Trials Registry, registration number: NCT030389, the first of February 2017, Retrospectively registered. |
| first_indexed | 2024-03-08T04:55:16Z |
| format | Article |
| id | doaj.art-23a9ea19d7d94d38838f2a56cb4b82b7 |
| institution | Directory Open Access Journal |
| issn | 2197-1153 |
| language | English |
| last_indexed | 2024-03-08T04:55:16Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Experimental Orthopaedics |
| spelling | doaj.art-23a9ea19d7d94d38838f2a56cb4b82b72024-02-07T15:16:41ZengWileyJournal of Experimental Orthopaedics2197-11532021-01-0181n/an/a10.1186/s40634-021-00332-3Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized studyE Guntz0C Vasseur1D Ifrim2A Louvard3J F Fils4Y Kapessidou5Department of AnesthesiologyHôpital Braine L’Alleud WaterlooUniversité Libre de Bruxelles (ULB)35 rue Wayez1420Braine l’Alleud‐WaterlooBelgiumDepartment of AnesthesiologyHôpital Braine L’Alleud WaterlooUniversité Libre de Bruxelles (ULB)35 rue Wayez1420Braine l’Alleud‐WaterlooBelgiumDepartment of AnesthesiologyHôpital Braine L’Alleud WaterlooUniversité Libre de Bruxelles (ULB)35 rue Wayez1420Braine l’Alleud‐WaterlooBelgiumDepartment of AnesthesiologyHôpital Braine L’Alleud WaterlooUniversité Libre de Bruxelles (ULB)35 rue Wayez1420Braine l’Alleud‐WaterlooBelgiumIndependant Biostatistician – Ars StatisticaNivellesBelgiumDepartment of AnesthesiologyCHU St PierreULB322 rue Haute1000BruxellesBelgiumAbstract Purpose The aim of this study was to compare intrathecal 1% chloroprocaine with 2% hyperbaric prilocaine in the setting of ambulatory knee arthroscopy. We hypothesized that complete resolution of the sensory block was faster with chloroprocaine. Methods Eighty patients scheduled for knee arthroscopy were included in this prospective randomized double‐blind study. Spinal anesthesia was performed with either chloroprocaine (50 mg) or hyperbaric prilocaine (50 mg). Characteristics of sensory and motor blocks and side effects were recorded. Results Mean time to full sensory block recovery was shorter with chloroprocaine (169 (56.1) min vs 248 (59.4)). The characteristics of the sensory blocks were similar at the T12 dermatome level between the two groups. Differences appeared at T10: the percentage of patients with a sensory block was higher, onset quicker and duration longer with hyperbaric prilocaine. The number of patients with a sensory block at T4 dermatome level in both groups was minimal. Times to full motor recovery were identical in both groups (85 (70–99) vs 86 (76–111) min). Time to spontaneous voiding was shorter with chloroprocaine (203 (57.6) min vs 287.3 (47.2) min). Incidence of side effects was low in both groups. Conclusions When considering the characteristics of the sensory block, the use of chloroprocaine may allow an earlier discharge of patients. Cephalic extension was to a higher dermatomal level and the sensory block at T10 level was of prolonged duration with hyperbaric prilocaine, suggesting that the choice between the two drugs should also be performed based on the level of the sensory block requested by the surgery. This study is registered in the US National Clinical Trials Registry, registration number: NCT030389, the first of February 2017, Retrospectively registered.https://doi.org/10.1186/s40634-021-00332-3Spinal anesthesiaHyperbaric prilocaineChloroprocaineProspective studySensory block |
| spellingShingle | E Guntz C Vasseur D Ifrim A Louvard J F Fils Y Kapessidou Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study Journal of Experimental Orthopaedics Spinal anesthesia Hyperbaric prilocaine Chloroprocaine Prospective study Sensory block |
| title | Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study |
| title_full | Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study |
| title_fullStr | Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study |
| title_full_unstemmed | Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study |
| title_short | Intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery? A prospective randomized study |
| title_sort | intrathecal chloroprocaine or hyperbaric prilocaine for ambulatory knee surgery a prospective randomized study |
| topic | Spinal anesthesia Hyperbaric prilocaine Chloroprocaine Prospective study Sensory block |
| url | https://doi.org/10.1186/s40634-021-00332-3 |
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