Simultaneous Increases in Intracellular Sodium and Tonicity Boost Antimicrobial Activity of Macrophages

Simultaneous Increases in Intracellular Sodium and Tonicity Boost Antimicrobial Activity of Macrophages

Inflamed and infected tissues can display increased local sodium (Na<sup>+</sup>) levels, which can have various effects on immune cells. In macrophages, high salt (HS) leads to a Na<sup>+</sup>/Ca<sup>2+</sup>-exchanger 1 (NCX1)-dependent increase in intracellula...

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Bibliographic Details
Main Authors: Luka Krampert, Thomas Ossner, Agnes Schröder, Valentin Schatz, Jonathan Jantsch
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
macrophages
Na<sup>+</sup>/K<sup>+</sup>-ATPase
cardiac glycosides
sodium
intracellular sodium
osmotic stress
Online Access:https://www.mdpi.com/2073-4409/12/24/2816

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