Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors
Osteopontin is a member of the proinflammatory cytokine network, a complex system that involves many chemokines, cytokines, and growth factors. The aim of the present study was to study the associations between osteopontin and a large number of chemokines, cytokines, and growth factors. We analyzed...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/8/908 |
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| author | Anders Larsson Johanna Helmersson-Karlqvist Lars Lind Johan Ärnlöv Tobias Rudholm Feldreich |
| author_facet | Anders Larsson Johanna Helmersson-Karlqvist Lars Lind Johan Ärnlöv Tobias Rudholm Feldreich |
| author_sort | Anders Larsson |
| collection | DOAJ |
| description | Osteopontin is a member of the proinflammatory cytokine network, a complex system that involves many chemokines, cytokines, and growth factors. The aim of the present study was to study the associations between osteopontin and a large number of chemokines, cytokines, and growth factors. We analyzed plasma and urine osteopontin in 652 men from the Uppsala Longitudinal Study of Adult Men (ULSAM) study cohort and compared the levels with the levels of eighty-five chemokines, cytokines, and growth factors. We found significant associations between plasma osteopontin and 37 plasma biomarkers in a model adjusted for age, and 28 of those plasma biomarkers were significant in a model also adjusting for cardiovascular risk factors. There were no significant associations after Bonferroni adjustment between urine osteopontin and any of the studied plasma cytokine biomarkers. This study shows that circulating osteopontin participates in a protein–protein interaction network of chemokines, cytokines, and growth factors. The network contains responses, pathways, and receptor binding interactions relating to cytokines, regulation of the immune system, and also regulation of apoptosis and intracellular signal transduction. |
| first_indexed | 2024-03-10T08:59:11Z |
| format | Article |
| id | doaj.art-23ab604a92404e35b4c348674bfee62d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T08:59:11Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-23ab604a92404e35b4c348674bfee62d2023-11-22T06:51:50ZengMDPI AGBiomedicines2227-90592021-07-019890810.3390/biomedicines9080908Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth FactorsAnders Larsson0Johanna Helmersson-Karlqvist1Lars Lind2Johan Ärnlöv3Tobias Rudholm Feldreich4Department of Medical Sciences, Uppsala University, 751 85 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, 751 85 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, 751 85 Uppsala, SwedenDivision of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, 171 77 Stockholm, SwedenSchool of Health and Social Sciences, Dalarna University, 791 88 Falun, SwedenOsteopontin is a member of the proinflammatory cytokine network, a complex system that involves many chemokines, cytokines, and growth factors. The aim of the present study was to study the associations between osteopontin and a large number of chemokines, cytokines, and growth factors. We analyzed plasma and urine osteopontin in 652 men from the Uppsala Longitudinal Study of Adult Men (ULSAM) study cohort and compared the levels with the levels of eighty-five chemokines, cytokines, and growth factors. We found significant associations between plasma osteopontin and 37 plasma biomarkers in a model adjusted for age, and 28 of those plasma biomarkers were significant in a model also adjusting for cardiovascular risk factors. There were no significant associations after Bonferroni adjustment between urine osteopontin and any of the studied plasma cytokine biomarkers. This study shows that circulating osteopontin participates in a protein–protein interaction network of chemokines, cytokines, and growth factors. The network contains responses, pathways, and receptor binding interactions relating to cytokines, regulation of the immune system, and also regulation of apoptosis and intracellular signal transduction.https://www.mdpi.com/2227-9059/9/8/908osteopontinplasmaurineproinflammatory cytokineschemokines |
| spellingShingle | Anders Larsson Johanna Helmersson-Karlqvist Lars Lind Johan Ärnlöv Tobias Rudholm Feldreich Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors Biomedicines osteopontin plasma urine proinflammatory cytokines chemokines |
| title | Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors |
| title_full | Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors |
| title_fullStr | Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors |
| title_full_unstemmed | Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors |
| title_short | Strong Associations between Plasma Osteopontin and Several Inflammatory Chemokines, Cytokines, and Growth Factors |
| title_sort | strong associations between plasma osteopontin and several inflammatory chemokines cytokines and growth factors |
| topic | osteopontin plasma urine proinflammatory cytokines chemokines |
| url | https://www.mdpi.com/2227-9059/9/8/908 |
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