CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity

CFTR dysfunction in smooth muscle drives TGFβ dependent airway hyperreactivity

Abstract Background The primary underlying defect in cystic fibrosis (CF) is disrupted ion transport in epithelia throughout the body. It is unclear if symptoms such as airway hyperreactivity (AHR) and increased airway smooth muscle (ASM) volume in people with CF are due to inherent abnormalities in...

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Bibliographic Details
Main Authors: Elizabeth L. Kramer, Kristin M. Hudock, Cynthia R. Davidson, John P. Clancy
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Respiratory Research
Subjects:
Cystic fibrosis
CFTR
Transforming growth factor beta
Airway smooth muscle
Airway hyperreactivity
Online Access:https://doi.org/10.1186/s12931-023-02495-2

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