Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration

Integrated Process for Capture and Purification of Virus-Like Particles: Enhancing Process Performance by Cross-Flow Filtration

Virus-like particles (VLPs) are emerging nanoscale protein assemblies applied as prophylactic vaccines and in development as therapeutic vaccines or cargo delivery systems. Downstream processing (DSP) of VLPs comes both with challenges and opportunities, depending on the complexity and size of the s...

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Bibliographic Details
Main Authors: Nils Hillebrandt, Philipp Vormittag, Nicolai Bluthardt, Annabelle Dietrich, Jürgen Hubbuch
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
virus-like particles
precipitation
cross-flow filtration
integrated processing
downstream processing
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00489/full

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