The Identification of Large Rearrangements Involving Intron 2 of the <i>CDH1</i> Gene in <i>BRCA1/2</i> Negative and Breast Cancer Susceptibility

The Identification of Large Rearrangements Involving Intron 2 of the <i>CDH1</i> Gene in <i>BRCA1/2</i> Negative and Breast Cancer Susceptibility

E-cadherin, a <i>CDH1</i> gene product, is a calcium-dependent cell–cell adhesion molecule playing a critical role in the establishment of epithelial architecture, maintenance of cell polarity, and differentiation. Germline pathogenic variants in the <i>CDH1</i> gene are asso...

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Bibliographic Details
Main Authors: Jihenne Ben Aissa-Haj, Hugo Pinheiro, François Cornelis, Molka Sebai, Didier Meseure, Adrien Briaux, Philippe Berteaux, Cedric Lefol, Gaëtan Des Guetz, Martine Trassard, Denise Stevens, François Vialard, Ivan Bieche, Catherine Noguès, Roseline Tang, Carla Oliveira, Dominique Stoppat-Lyonnet, Rosette Lidereau, Etienne Rouleau
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Genes
Subjects:
breast carcinoma
gastric carcinoma
<i>CDH1</i> rearrangements
CNV
CGH array
<i>BRCA1/2</i> negative cases
Online Access:https://www.mdpi.com/2073-4425/13/12/2213

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