Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects
Abstract Lignin has enormous potential as a renewable feedstock for depolymerizing to numerous high-value chemicals. However, lignin depolymerization is challenging owing to its recalcitrant, heterogenous, and limited water-soluble nature. From the standpoint of environmental friendliness and sustai...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-03-01
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| Series: | Bioresources and Bioprocessing |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40643-023-00640-9 |
| _version_ | 1797860003093151744 |
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| author | Man Zhou Olugbenga Abiola Fakayode Manni Ren Haoxin Li Jiakang Liang Abu ElGasim Ahmed Yagoub Zhiliang Fan Cunshan Zhou |
| author_facet | Man Zhou Olugbenga Abiola Fakayode Manni Ren Haoxin Li Jiakang Liang Abu ElGasim Ahmed Yagoub Zhiliang Fan Cunshan Zhou |
| author_sort | Man Zhou |
| collection | DOAJ |
| description | Abstract Lignin has enormous potential as a renewable feedstock for depolymerizing to numerous high-value chemicals. However, lignin depolymerization is challenging owing to its recalcitrant, heterogenous, and limited water-soluble nature. From the standpoint of environmental friendliness and sustainability, enzymatic depolymerization of lignin is of great significance. Notably, laccases play an essential role in the enzymatic depolymerization of lignin and are considered the ultimate green catalysts. Deep eutectic solvent (DES), an efficient media in biocatalysis, are increasingly recognized as the newest and utmost green solvent that highly dissolves lignin. This review centers on a lignin depolymerization strategy by harnessing the good lignin fractionating capability of DES and the high substrate and product selectivity of laccase. Recent progress and insights into the laccase–DES interactions, protein engineering strategies for improving DES compatibility with laccase, and controlling the product selectivity of lignin degradation by laccase or in DES systems are extensively provided. Lastly, the challenges and prospects of the alliance between DES and laccase for lignin depolymerization are discussed. The collaboration of laccase and DES provides a great opportunity to develop an enzymatic route for lignin depolymerization. Graphical Abstract |
| first_indexed | 2024-04-09T21:38:42Z |
| format | Article |
| id | doaj.art-23af395f3fa243ae9328215ad4a268d2 |
| institution | Directory Open Access Journal |
| issn | 2197-4365 |
| language | English |
| last_indexed | 2024-04-09T21:38:42Z |
| publishDate | 2023-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bioresources and Bioprocessing |
| spelling | doaj.art-23af395f3fa243ae9328215ad4a268d22023-03-26T11:05:43ZengSpringerOpenBioresources and Bioprocessing2197-43652023-03-0110112210.1186/s40643-023-00640-9Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospectsMan Zhou0Olugbenga Abiola Fakayode1Manni Ren2Haoxin Li3Jiakang Liang4Abu ElGasim Ahmed Yagoub5Zhiliang Fan6Cunshan Zhou7School of Food and Biological Engineering, Jiangsu UniversitySchool of Food and Biological Engineering, Jiangsu UniversitySchool of Food and Biological Engineering, Jiangsu UniversitySchool of Food and Biological Engineering, Jiangsu UniversitySchool of Food and Biological Engineering, Jiangsu UniversityDepartment of Food Science and Nutrition, King Saud UniversityBiological and Agricultural Engineering Department, University of CaliforniaSchool of Food and Biological Engineering, Jiangsu UniversityAbstract Lignin has enormous potential as a renewable feedstock for depolymerizing to numerous high-value chemicals. However, lignin depolymerization is challenging owing to its recalcitrant, heterogenous, and limited water-soluble nature. From the standpoint of environmental friendliness and sustainability, enzymatic depolymerization of lignin is of great significance. Notably, laccases play an essential role in the enzymatic depolymerization of lignin and are considered the ultimate green catalysts. Deep eutectic solvent (DES), an efficient media in biocatalysis, are increasingly recognized as the newest and utmost green solvent that highly dissolves lignin. This review centers on a lignin depolymerization strategy by harnessing the good lignin fractionating capability of DES and the high substrate and product selectivity of laccase. Recent progress and insights into the laccase–DES interactions, protein engineering strategies for improving DES compatibility with laccase, and controlling the product selectivity of lignin degradation by laccase or in DES systems are extensively provided. Lastly, the challenges and prospects of the alliance between DES and laccase for lignin depolymerization are discussed. The collaboration of laccase and DES provides a great opportunity to develop an enzymatic route for lignin depolymerization. Graphical Abstracthttps://doi.org/10.1186/s40643-023-00640-9Lignin depolymerizationDeep eutectic solventsLaccaseBiocatalysisLignocellulosic biomass |
| spellingShingle | Man Zhou Olugbenga Abiola Fakayode Manni Ren Haoxin Li Jiakang Liang Abu ElGasim Ahmed Yagoub Zhiliang Fan Cunshan Zhou Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects Bioresources and Bioprocessing Lignin depolymerization Deep eutectic solvents Laccase Biocatalysis Lignocellulosic biomass |
| title | Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects |
| title_full | Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects |
| title_fullStr | Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects |
| title_full_unstemmed | Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects |
| title_short | Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects |
| title_sort | laccase catalyzed lignin depolymerization in deep eutectic solvents challenges and prospects |
| topic | Lignin depolymerization Deep eutectic solvents Laccase Biocatalysis Lignocellulosic biomass |
| url | https://doi.org/10.1186/s40643-023-00640-9 |
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