Adjuvant therapy in premenopausal women with hormone-dependent breast cancer
In recent years, several studies have indicated that aromatase inhibitors (AIS) combined with a gonadotropin-releasing hormone agonist (GnRH agonist) are safe and effective in premenopausal patients with hormone receptor positive (HR+) breast cancer (BCA). The ABCSG-12 trial has shown a comparable D...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2018-11-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/2750 |
| _version_ | 1827962331369308160 |
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| author | V. F. Semiglazov V. Yu. Lifanova V. S. Appolonova |
| author_facet | V. F. Semiglazov V. Yu. Lifanova V. S. Appolonova |
| author_sort | V. F. Semiglazov |
| collection | DOAJ |
| description | In recent years, several studies have indicated that aromatase inhibitors (AIS) combined with a gonadotropin-releasing hormone agonist (GnRH agonist) are safe and effective in premenopausal patients with hormone receptor positive (HR+) breast cancer (BCA). The ABCSG-12 trial has shown a comparable DFS for 3-eyar adjuvant therapy with anastrazol-goserelin and tamoxifengoserelin. However a combined analysis of the data from SOFT and TEXT trials demonstrated that compared with tamoxifen plus ovarian suppression, adjuvant endocrine therapy with exemestane plus GnRH agonist (Triptorelin) in premenopausal patients with a significant improved DFS and an extended interval without distant recurrence. The differing results emerging from ABCSG-12 and the TEXT and SOFT trials misht be related to higher statistical power in the combined analysis. |
| first_indexed | 2024-04-09T16:41:10Z |
| format | Article |
| id | doaj.art-23b32ceaa8bd4f309303e08bf3f10886 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:41:10Z |
| publishDate | 2018-11-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-23b32ceaa8bd4f309303e08bf3f108862023-04-23T06:56:40ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-11-01019737510.21518/2079-701X-2018-19-73-752692Adjuvant therapy in premenopausal women with hormone-dependent breast cancerV. F. Semiglazov0V. Yu. Lifanova1V. S. Appolonova2Petrov National Medical Cancer Research Centre, the Ministry of Russia, St.PetersburgPetrov National Medical Cancer Research Centre, the Ministry of Russia, St.Petersburg; Modern Medical Technology Clinic, St.PetersburgPetrov National Medical Cancer Research Centre, the Ministry of Russia, St.PetersburgIn recent years, several studies have indicated that aromatase inhibitors (AIS) combined with a gonadotropin-releasing hormone agonist (GnRH agonist) are safe and effective in premenopausal patients with hormone receptor positive (HR+) breast cancer (BCA). The ABCSG-12 trial has shown a comparable DFS for 3-eyar adjuvant therapy with anastrazol-goserelin and tamoxifengoserelin. However a combined analysis of the data from SOFT and TEXT trials demonstrated that compared with tamoxifen plus ovarian suppression, adjuvant endocrine therapy with exemestane plus GnRH agonist (Triptorelin) in premenopausal patients with a significant improved DFS and an extended interval without distant recurrence. The differing results emerging from ABCSG-12 and the TEXT and SOFT trials misht be related to higher statistical power in the combined analysis.https://www.med-sovet.pro/jour/article/view/2750breast canceraromatase inhibitorspremenopausal womengnrh agonist |
| spellingShingle | V. F. Semiglazov V. Yu. Lifanova V. S. Appolonova Adjuvant therapy in premenopausal women with hormone-dependent breast cancer Медицинский совет breast cancer aromatase inhibitors premenopausal women gnrh agonist |
| title | Adjuvant therapy in premenopausal women with hormone-dependent breast cancer |
| title_full | Adjuvant therapy in premenopausal women with hormone-dependent breast cancer |
| title_fullStr | Adjuvant therapy in premenopausal women with hormone-dependent breast cancer |
| title_full_unstemmed | Adjuvant therapy in premenopausal women with hormone-dependent breast cancer |
| title_short | Adjuvant therapy in premenopausal women with hormone-dependent breast cancer |
| title_sort | adjuvant therapy in premenopausal women with hormone dependent breast cancer |
| topic | breast cancer aromatase inhibitors premenopausal women gnrh agonist |
| url | https://www.med-sovet.pro/jour/article/view/2750 |
| work_keys_str_mv | AT vfsemiglazov adjuvanttherapyinpremenopausalwomenwithhormonedependentbreastcancer AT vyulifanova adjuvanttherapyinpremenopausalwomenwithhormonedependentbreastcancer AT vsappolonova adjuvanttherapyinpremenopausalwomenwithhormonedependentbreastcancer |