Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy
Immunotherapy is an emerging method for the treatment of cervical cancer and is more effective than surgery and radiotherapy, especially for recurrent cervical cancer. However, immunotherapy is limited by adverse effects in clinical practice. In recent years, nanotechnology has been widely used for...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1065793/full |
| _version_ | 1811292768578830336 |
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| author | Xuyan Zhou Haiying Lian Hongpeng Li Meiling Fan Wei Xu Ye Jin |
| author_facet | Xuyan Zhou Haiying Lian Hongpeng Li Meiling Fan Wei Xu Ye Jin |
| author_sort | Xuyan Zhou |
| collection | DOAJ |
| description | Immunotherapy is an emerging method for the treatment of cervical cancer and is more effective than surgery and radiotherapy, especially for recurrent cervical cancer. However, immunotherapy is limited by adverse effects in clinical practice. In recent years, nanotechnology has been widely used for tumor diagnosis, drug delivery, and targeted therapy. In the setting of cervical cancer, nanotechnology can be used to actively or passively target immunotherapeutic agents to tumor sites, thereby enhancing local drug delivery, reducing drug adverse effects, achieving immunomodulation, improving the tumor immune microenvironment, and optimizing treatment efficacy. In this review, we highlight the current status of therapeutic vaccines and adoptive cell therapy in cervical cancer immunotherapy, as well as the application of lipid carriers, polymeric nanoparticles, inorganic nanoparticles, and exosomes in this context. |
| first_indexed | 2024-04-13T04:51:22Z |
| format | Article |
| id | doaj.art-23b400462b044ab7bdc36469a230883f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T04:51:22Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-23b400462b044ab7bdc36469a230883f2022-12-22T03:01:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-12-011310.3389/fphar.2022.10657931065793Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapyXuyan Zhou0Haiying Lian1Hongpeng Li2Meiling Fan3Wei Xu4Ye Jin5School of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaGynecology Department, Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaSchool of Pharmacy, Changchun University of Chinese Medicine, Changchun, ChinaImmunotherapy is an emerging method for the treatment of cervical cancer and is more effective than surgery and radiotherapy, especially for recurrent cervical cancer. However, immunotherapy is limited by adverse effects in clinical practice. In recent years, nanotechnology has been widely used for tumor diagnosis, drug delivery, and targeted therapy. In the setting of cervical cancer, nanotechnology can be used to actively or passively target immunotherapeutic agents to tumor sites, thereby enhancing local drug delivery, reducing drug adverse effects, achieving immunomodulation, improving the tumor immune microenvironment, and optimizing treatment efficacy. In this review, we highlight the current status of therapeutic vaccines and adoptive cell therapy in cervical cancer immunotherapy, as well as the application of lipid carriers, polymeric nanoparticles, inorganic nanoparticles, and exosomes in this context.https://www.frontiersin.org/articles/10.3389/fphar.2022.1065793/fullcervical cancernanotechnologyimmunotherapytherapeutic vaccineadoptive cell therapynanocarriers |
| spellingShingle | Xuyan Zhou Haiying Lian Hongpeng Li Meiling Fan Wei Xu Ye Jin Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy Frontiers in Pharmacology cervical cancer nanotechnology immunotherapy therapeutic vaccine adoptive cell therapy nanocarriers |
| title | Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy |
| title_full | Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy |
| title_fullStr | Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy |
| title_full_unstemmed | Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy |
| title_short | Nanotechnology in cervical cancer immunotherapy: Therapeutic vaccines and adoptive cell therapy |
| title_sort | nanotechnology in cervical cancer immunotherapy therapeutic vaccines and adoptive cell therapy |
| topic | cervical cancer nanotechnology immunotherapy therapeutic vaccine adoptive cell therapy nanocarriers |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1065793/full |
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