Could Nanotheranostics be the Answer to the Coronavirus Crisis?
Abstract The COVID‐19 pandemic is expanding worldwide. This pandemic associated with COVID‐19 placed the spotlight on how bacterial (e.g., methicillin‐resistant Staphylococcus aureus) co‐infections may impact responses to coronavirus. In this review the ways in which nanoparticles can contain and ra...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-06-01
|
| Series: | Global Challenges |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/gch2.202000112 |
| _version_ | 1818448755080298496 |
|---|---|
| author | Dina A. Mosselhy Mhd Adel Assad Tarja Sironen Mady Elbahri |
| author_facet | Dina A. Mosselhy Mhd Adel Assad Tarja Sironen Mady Elbahri |
| author_sort | Dina A. Mosselhy |
| collection | DOAJ |
| description | Abstract The COVID‐19 pandemic is expanding worldwide. This pandemic associated with COVID‐19 placed the spotlight on how bacterial (e.g., methicillin‐resistant Staphylococcus aureus) co‐infections may impact responses to coronavirus. In this review the ways in which nanoparticles can contain and rapidly diagnose COVID‐19 under the umbrella of nanotheranostics (i.e., smart, single agents combining nanodiagnostics and nanotherapeutics) are elaborated. The present work provides new insights into the promising incorporation of antiviral nanotheranostics into nanostructured materials, including electrospun fibers with tailored pore sizes and hydrophobicity, namely “superhydrophobic self‐disinfecting electrospun facemasks/fabrics (SSEF).” SSEFs are proposed as smart alternatives to address the drawbacks of N95 respirators. The challenges of coronavirus containment are underscored, literature is reviewed, and “top‐five suggestions” for containing COVID‐19 are offered, including: i) preventive appraisals—avoiding needless hospital admission and practicing frequent hand washing (from 20 to 60 s). ii) Diagnostics—highly recommending nanodiagnostics, detecting COVID‐19 within 10 min. iii) Therapeutics—expanding nanotherapeutics to treat COVID‐19 and bacterial co‐infections after safety assessments and clinical trials. iv) Multipronged and multinational, including China, collaborative appraisals. v) Humanitarian compassion to traverse this pandemic in a united way. |
| first_indexed | 2024-12-14T20:24:33Z |
| format | Article |
| id | doaj.art-23b4861f176f4ef3932baead6611a771 |
| institution | Directory Open Access Journal |
| issn | 2056-6646 |
| language | English |
| last_indexed | 2024-12-14T20:24:33Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Global Challenges |
| spelling | doaj.art-23b4861f176f4ef3932baead6611a7712022-12-21T22:48:39ZengWileyGlobal Challenges2056-66462021-06-0156n/an/a10.1002/gch2.202000112Could Nanotheranostics be the Answer to the Coronavirus Crisis?Dina A. Mosselhy0Mhd Adel Assad1Tarja Sironen2Mady Elbahri3Nanochemistry and Nanoengineering Department of Chemistry and Materials Science School of Chemical Engineering Aalto University Espoo 02150 FinlandNanochemistry and Nanoengineering Department of Chemistry and Materials Science School of Chemical Engineering Aalto University Espoo 02150 FinlandDepartment of Virology Faculty of Medicine University of Helsinki P.O. Box 21 Helsinki 00014 FinlandNanochemistry and Nanoengineering Department of Chemistry and Materials Science School of Chemical Engineering Aalto University Espoo 02150 FinlandAbstract The COVID‐19 pandemic is expanding worldwide. This pandemic associated with COVID‐19 placed the spotlight on how bacterial (e.g., methicillin‐resistant Staphylococcus aureus) co‐infections may impact responses to coronavirus. In this review the ways in which nanoparticles can contain and rapidly diagnose COVID‐19 under the umbrella of nanotheranostics (i.e., smart, single agents combining nanodiagnostics and nanotherapeutics) are elaborated. The present work provides new insights into the promising incorporation of antiviral nanotheranostics into nanostructured materials, including electrospun fibers with tailored pore sizes and hydrophobicity, namely “superhydrophobic self‐disinfecting electrospun facemasks/fabrics (SSEF).” SSEFs are proposed as smart alternatives to address the drawbacks of N95 respirators. The challenges of coronavirus containment are underscored, literature is reviewed, and “top‐five suggestions” for containing COVID‐19 are offered, including: i) preventive appraisals—avoiding needless hospital admission and practicing frequent hand washing (from 20 to 60 s). ii) Diagnostics—highly recommending nanodiagnostics, detecting COVID‐19 within 10 min. iii) Therapeutics—expanding nanotherapeutics to treat COVID‐19 and bacterial co‐infections after safety assessments and clinical trials. iv) Multipronged and multinational, including China, collaborative appraisals. v) Humanitarian compassion to traverse this pandemic in a united way.https://doi.org/10.1002/gch2.202000112anti‐coronavirusappraisalscoronaviruselectrospun facemasksnanodiagnosticsnanoparticles |
| spellingShingle | Dina A. Mosselhy Mhd Adel Assad Tarja Sironen Mady Elbahri Could Nanotheranostics be the Answer to the Coronavirus Crisis? Global Challenges anti‐coronavirus appraisals coronavirus electrospun facemasks nanodiagnostics nanoparticles |
| title | Could Nanotheranostics be the Answer to the Coronavirus Crisis? |
| title_full | Could Nanotheranostics be the Answer to the Coronavirus Crisis? |
| title_fullStr | Could Nanotheranostics be the Answer to the Coronavirus Crisis? |
| title_full_unstemmed | Could Nanotheranostics be the Answer to the Coronavirus Crisis? |
| title_short | Could Nanotheranostics be the Answer to the Coronavirus Crisis? |
| title_sort | could nanotheranostics be the answer to the coronavirus crisis |
| topic | anti‐coronavirus appraisals coronavirus electrospun facemasks nanodiagnostics nanoparticles |
| url | https://doi.org/10.1002/gch2.202000112 |
| work_keys_str_mv | AT dinaamosselhy couldnanotheranosticsbetheanswertothecoronaviruscrisis AT mhdadelassad couldnanotheranosticsbetheanswertothecoronaviruscrisis AT tarjasironen couldnanotheranosticsbetheanswertothecoronaviruscrisis AT madyelbahri couldnanotheranosticsbetheanswertothecoronaviruscrisis |