Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice

Urotensin II Induces ER Stress and EMT and Increase Extracellular Matrix Production in Renal Tubular Epithelial Cell in Early Diabetic Mice

Background/Aims: Urotensin II (UII) and its receptor are highly expressed in the kidney tissue of patients with diabetic nephropathy (DN). The aim of this study is to examine the roles of UII in the induction of endoplasmic reticulum stress (ER stress) and Epithelial-mesenchymal transition (EMT) in...

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Bibliographic Details
Main Authors: Xin-Xin Pang, Qiong Bai, Fei Wu, Guan-Jong Chen, Ai-Hua Zhang, Chao-Shu Tang
Format: Article
Language:English
Published: Karger Publishers 2016-07-01
Series:Kidney & Blood Pressure Research
Subjects:
Urotensin II
Diabetic Nephropathy
EMT
Endoplasmic reticulum stress
Online Access:http://www.karger.com/Article/FullText/443445

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