Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice
Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most countries. To date, microbiota-directed foods selectively promote the targeted human gut microbes, providing a strategy for A. muciniphila enhancement. Multiple studies have indicated...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-01-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023001064 |
| _version_ | 1797694158774730752 |
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| author | Xiaoxiang Gao Chenbo Yue Ruocen Tian Leilei Yu Fengwei Tian Jianxin Zhao Wei Chen Qixiao Zhai |
| author_facet | Xiaoxiang Gao Chenbo Yue Ruocen Tian Leilei Yu Fengwei Tian Jianxin Zhao Wei Chen Qixiao Zhai |
| author_sort | Xiaoxiang Gao |
| collection | DOAJ |
| description | Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most countries. To date, microbiota-directed foods selectively promote the targeted human gut microbes, providing a strategy for A. muciniphila enhancement. Multiple studies have indicated the potential regulation of the polyphenol on A. muciniphila. Therefore, a polyphenol screening based on A. muciniphila upregulation was performed in mice. Chlorogenic acid (CGA) exhibited a greater response to A. muciniphila upregulation. Furthermore, we found that CGA did not directly promote A. muciniphila growth or mucin secretion. Microbiome and metabolomics revealed that the increased abundance of A. muciniphila resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid, β-hydroxybutyrate, and N-acetyl-lactosamine. Finally, to confirm the regulation of CGA on A. muciniphila under disease conditions, high-fat diet-fed mice were established. The results showed CGA promoted A. muciniphila growth, and we expectedly found that CGA suppressed the augment in body weight of mice, significantly attenuated adipose tissue abnormality, provided liver protection and improved gut barrier integrity. These results suggest that CGA inhibits the development of obesity. Overall, our results indicate that microbiota-directed food is a promising approach for the treatment of obesity. |
| first_indexed | 2024-03-12T02:53:53Z |
| format | Article |
| id | doaj.art-23b79f79d642475ebb3a6bba82c9c574 |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T02:53:53Z |
| publishDate | 2024-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-23b79f79d642475ebb3a6bba82c9c5742023-09-03T15:26:18ZengTsinghua University PressFood Science and Human Wellness2213-45302024-01-0113190100Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in miceXiaoxiang Gao0Chenbo Yue1Ruocen Tian2Leilei Yu3Fengwei Tian4Jianxin Zhao5Wei Chen6Qixiao Zhai7State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Corresponding author at: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.Akkermansia muciniphila play an important in ameliorating obesity but is not allowed for direct consumption in most countries. To date, microbiota-directed foods selectively promote the targeted human gut microbes, providing a strategy for A. muciniphila enhancement. Multiple studies have indicated the potential regulation of the polyphenol on A. muciniphila. Therefore, a polyphenol screening based on A. muciniphila upregulation was performed in mice. Chlorogenic acid (CGA) exhibited a greater response to A. muciniphila upregulation. Furthermore, we found that CGA did not directly promote A. muciniphila growth or mucin secretion. Microbiome and metabolomics revealed that the increased abundance of A. muciniphila resulted from the inhibition of CGA on Desulfovibrio and Alistipes and the influence of docosahexaenoic acid, β-hydroxybutyrate, and N-acetyl-lactosamine. Finally, to confirm the regulation of CGA on A. muciniphila under disease conditions, high-fat diet-fed mice were established. The results showed CGA promoted A. muciniphila growth, and we expectedly found that CGA suppressed the augment in body weight of mice, significantly attenuated adipose tissue abnormality, provided liver protection and improved gut barrier integrity. These results suggest that CGA inhibits the development of obesity. Overall, our results indicate that microbiota-directed food is a promising approach for the treatment of obesity.http://www.sciencedirect.com/science/article/pii/S2213453023001064Akkermansia muciniphilapolyphenolchlorogenic acidobesity |
| spellingShingle | Xiaoxiang Gao Chenbo Yue Ruocen Tian Leilei Yu Fengwei Tian Jianxin Zhao Wei Chen Qixiao Zhai Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice Food Science and Human Wellness Akkermansia muciniphila polyphenol chlorogenic acid obesity |
| title | Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice |
| title_full | Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice |
| title_fullStr | Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice |
| title_full_unstemmed | Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice |
| title_short | Akkermansia muciniphila-directed polyphenol chlorogenic acid intervention for obesity in mice |
| title_sort | akkermansia muciniphila directed polyphenol chlorogenic acid intervention for obesity in mice |
| topic | Akkermansia muciniphila polyphenol chlorogenic acid obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023001064 |
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