The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer
Purpose: This retrospective cohort study was to assess the prognostic value of preoperative geriatric nutritional risk index (GNRI) on survival outcomes for patients with locally advanced oral squamous cell carcinoma (LAOSCC). Methods: Patients with LAOSCC receiving upfront radical surgery at a sing...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664623002516 |
| _version_ | 1827591665816174592 |
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| author | Yi-Lun Shih Hui-Ching Chuang Yu-Tsai Lin Chih-Yen Chien Chao-Hui Yang Chi-Chih Lai Yan-Ye Su Yao-Te Tsai Hui Lu Ming-Hsien Tsai |
| author_facet | Yi-Lun Shih Hui-Ching Chuang Yu-Tsai Lin Chih-Yen Chien Chao-Hui Yang Chi-Chih Lai Yan-Ye Su Yao-Te Tsai Hui Lu Ming-Hsien Tsai |
| author_sort | Yi-Lun Shih |
| collection | DOAJ |
| description | Purpose: This retrospective cohort study was to assess the prognostic value of preoperative geriatric nutritional risk index (GNRI) on survival outcomes for patients with locally advanced oral squamous cell carcinoma (LAOSCC). Methods: Patients with LAOSCC receiving upfront radical surgery at a single institute from January 2007 to February 2017 were enrolled. The primary outcomes in the study were 5-year overall survival (OS) and cancer-specific survival (CSS) rates, and a nomogram based on GNRI and other clinical-pathological factors was established for individualized OS prediction. Results: There were 343 patients enrolled in this study. The optimal cut-off value of GNRI was observed to be 97.8. Patients in the high-GNRI group (GNRI ≥97.8) had statistically significantly better outcomes in 5-year OS (74.7% vs. 57.2%, p = 0.001) and CSS (82.2% vs. 68.9%, p = 0.005) when compared with the low-GNRI group (GNRI <97.8). In Cox models, low GNRI remained an independent negative prognosticator of OS (HR: 1.6; 95% CI: 1.124–2.277; p = 0.009) and CSS (HR: 1.907; 95% CI: 1.219–2.984; p = 0.005). The c-index of the proposed nomogram, incorporating assorted clinicopathological factors and GNRI, had a statistically significant increase compared with the predictive nomogram constructed by the TNM staging system alone (0.692 vs. 0.637, p < 0.001).” Conclusion: Preoperative GNRI is an independent prognostic factor of OS and CSS in patients with LAOSCC. A multivariate nomogram that includes GNRI may better help us to accurately estimate individual survival outcomes. |
| first_indexed | 2024-03-09T01:35:56Z |
| format | Article |
| id | doaj.art-23b8497603b64e17819dd0b896c4edcc |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-03-09T01:35:56Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-23b8497603b64e17819dd0b896c4edcc2023-12-09T06:04:22ZengElsevierJournal of the Formosan Medical Association0929-66462023-12-011221212961304The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancerYi-Lun Shih0Hui-Ching Chuang1Yu-Tsai Lin2Chih-Yen Chien3Chao-Hui Yang4Chi-Chih Lai5Yan-Ye Su6Yao-Te Tsai7Hui Lu8Ming-Hsien Tsai9Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDepartment of Otolaryngology, ChiaYi Chang Gung Memorial Hospital, ChiaYi, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Kaohsiung Chang Gung Head and Neck Oncology Group, Cancer Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital.Purpose: This retrospective cohort study was to assess the prognostic value of preoperative geriatric nutritional risk index (GNRI) on survival outcomes for patients with locally advanced oral squamous cell carcinoma (LAOSCC). Methods: Patients with LAOSCC receiving upfront radical surgery at a single institute from January 2007 to February 2017 were enrolled. The primary outcomes in the study were 5-year overall survival (OS) and cancer-specific survival (CSS) rates, and a nomogram based on GNRI and other clinical-pathological factors was established for individualized OS prediction. Results: There were 343 patients enrolled in this study. The optimal cut-off value of GNRI was observed to be 97.8. Patients in the high-GNRI group (GNRI ≥97.8) had statistically significantly better outcomes in 5-year OS (74.7% vs. 57.2%, p = 0.001) and CSS (82.2% vs. 68.9%, p = 0.005) when compared with the low-GNRI group (GNRI <97.8). In Cox models, low GNRI remained an independent negative prognosticator of OS (HR: 1.6; 95% CI: 1.124–2.277; p = 0.009) and CSS (HR: 1.907; 95% CI: 1.219–2.984; p = 0.005). The c-index of the proposed nomogram, incorporating assorted clinicopathological factors and GNRI, had a statistically significant increase compared with the predictive nomogram constructed by the TNM staging system alone (0.692 vs. 0.637, p < 0.001).” Conclusion: Preoperative GNRI is an independent prognostic factor of OS and CSS in patients with LAOSCC. A multivariate nomogram that includes GNRI may better help us to accurately estimate individual survival outcomes.http://www.sciencedirect.com/science/article/pii/S0929664623002516Geriatric nutritional risk indexOral cancerAdvanced stageNutritionPrognosis |
| spellingShingle | Yi-Lun Shih Hui-Ching Chuang Yu-Tsai Lin Chih-Yen Chien Chao-Hui Yang Chi-Chih Lai Yan-Ye Su Yao-Te Tsai Hui Lu Ming-Hsien Tsai The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer Journal of the Formosan Medical Association Geriatric nutritional risk index Oral cancer Advanced stage Nutrition Prognosis |
| title | The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer |
| title_full | The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer |
| title_fullStr | The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer |
| title_full_unstemmed | The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer |
| title_short | The prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer |
| title_sort | prognostic utility of preoperative geriatric nutritional risk index on survival outcomes of locally advanced oral cancer |
| topic | Geriatric nutritional risk index Oral cancer Advanced stage Nutrition Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S0929664623002516 |
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