From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation
Chronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP is intervertebral disc degeneration (IDD), often triggered by intervertebral disc (IVD) inflammation. Inflammation of the IVD is divided into Septic and Aseptic inflamm...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1303645/full |
| _version_ | 1797339130983612416 |
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| author | Shuhan Yang Shaoze Jing Shanxi Wang Fajing Jia |
| author_facet | Shuhan Yang Shaoze Jing Shanxi Wang Fajing Jia |
| author_sort | Shuhan Yang |
| collection | DOAJ |
| description | Chronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP is intervertebral disc degeneration (IDD), often triggered by intervertebral disc (IVD) inflammation. Inflammation of the IVD is divided into Septic and Aseptic inflammation. Conservative therapy and surgical treatment often fail to address the root cause of IDD. Recent advances in the treatment of IVD infection and inflammation range from antibiotics and small-molecule drugs to cellular therapies, biological agents, and innovative biomaterials. This review sheds light on the complex mechanisms of IVD inflammation and physiological and biochemical processes of IDD. Furthermore, it provides an overview of recent research developments in this area, intending to identify novel therapeutic targets and guide future clinical strategies for effectively treating IVD-related conditions. |
| first_indexed | 2024-03-08T09:41:29Z |
| format | Article |
| id | doaj.art-23b900be54d24788a6de911ff40c16f3 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-08T09:41:29Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-23b900be54d24788a6de911ff40c16f32024-01-30T04:24:18ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-01-011410.3389/fcimb.2024.13036451303645From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammationShuhan Yang0Shaoze Jing1Shanxi Wang2Fajing Jia3Department of Orthopedics, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Orthopedics, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaDepartment of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of General Practice, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, ChinaChronic low back pain (LBP) is an increasingly prevalent issue, especially among aging populations. A major underlying cause of LBP is intervertebral disc degeneration (IDD), often triggered by intervertebral disc (IVD) inflammation. Inflammation of the IVD is divided into Septic and Aseptic inflammation. Conservative therapy and surgical treatment often fail to address the root cause of IDD. Recent advances in the treatment of IVD infection and inflammation range from antibiotics and small-molecule drugs to cellular therapies, biological agents, and innovative biomaterials. This review sheds light on the complex mechanisms of IVD inflammation and physiological and biochemical processes of IDD. Furthermore, it provides an overview of recent research developments in this area, intending to identify novel therapeutic targets and guide future clinical strategies for effectively treating IVD-related conditions.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1303645/fullintervertebral discinfectioninflammationlow back paintreatment |
| spellingShingle | Shuhan Yang Shaoze Jing Shanxi Wang Fajing Jia From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation Frontiers in Cellular and Infection Microbiology intervertebral disc infection inflammation low back pain treatment |
| title | From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation |
| title_full | From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation |
| title_fullStr | From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation |
| title_full_unstemmed | From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation |
| title_short | From drugs to biomaterials: a review of emerging therapeutic strategies for intervertebral disc inflammation |
| title_sort | from drugs to biomaterials a review of emerging therapeutic strategies for intervertebral disc inflammation |
| topic | intervertebral disc infection inflammation low back pain treatment |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1303645/full |
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