CK2 and the Hallmarks of Cancer
Cancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved serine/threonine kinase, constitutively active and ubiquitously expressed in eukaryotes. With over 500 known substrates and being es...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1987 |
| _version_ | 1827600620275630080 |
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| author | May-Britt Firnau Angela Brieger |
| author_facet | May-Britt Firnau Angela Brieger |
| author_sort | May-Britt Firnau |
| collection | DOAJ |
| description | Cancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved serine/threonine kinase, constitutively active and ubiquitously expressed in eukaryotes. With over 500 known substrates and being estimated to be responsible for up to 10% of the human phosphoproteome, it is of significant importance. A broad spectrum of diverse types of cancer cells has been already shown to rely on disturbed CK2 levels for their survival. The hallmarks of cancer provide a rationale for understanding cancer’s common traits. They constitute the maintenance of proliferative signaling, evasion of growth suppressors, resisting cell death, enabling of replicative immortality, induction of angiogenesis, the activation of invasion and metastasis, as well as avoidance of immune destruction and dysregulation of cellular energetics. In this work, we have compiled evidence from the literature suggesting that CK2 modulates all hallmarks of cancer, thereby promoting oncogenesis and operating as a cancer driver by creating a cellular environment favorable to neoplasia. |
| first_indexed | 2024-03-09T04:39:46Z |
| format | Article |
| id | doaj.art-23bc00d8bc88451b863af38f4c7409f7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T04:39:46Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-23bc00d8bc88451b863af38f4c7409f72023-12-03T13:22:02ZengMDPI AGBiomedicines2227-90592022-08-01108198710.3390/biomedicines10081987CK2 and the Hallmarks of CancerMay-Britt Firnau0Angela Brieger1Department of Internal Medicine I, Biomedical Research Laboratory, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, GermanyDepartment of Internal Medicine I, Biomedical Research Laboratory, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, GermanyCancer is a leading cause of death worldwide. Casein kinase 2 (CK2) is commonly dysregulated in cancer, impacting diverse molecular pathways. CK2 is a highly conserved serine/threonine kinase, constitutively active and ubiquitously expressed in eukaryotes. With over 500 known substrates and being estimated to be responsible for up to 10% of the human phosphoproteome, it is of significant importance. A broad spectrum of diverse types of cancer cells has been already shown to rely on disturbed CK2 levels for their survival. The hallmarks of cancer provide a rationale for understanding cancer’s common traits. They constitute the maintenance of proliferative signaling, evasion of growth suppressors, resisting cell death, enabling of replicative immortality, induction of angiogenesis, the activation of invasion and metastasis, as well as avoidance of immune destruction and dysregulation of cellular energetics. In this work, we have compiled evidence from the literature suggesting that CK2 modulates all hallmarks of cancer, thereby promoting oncogenesis and operating as a cancer driver by creating a cellular environment favorable to neoplasia.https://www.mdpi.com/2227-9059/10/8/1987Casein kinase 2CK2cancerhallmarks of cancer |
| spellingShingle | May-Britt Firnau Angela Brieger CK2 and the Hallmarks of Cancer Biomedicines Casein kinase 2 CK2 cancer hallmarks of cancer |
| title | CK2 and the Hallmarks of Cancer |
| title_full | CK2 and the Hallmarks of Cancer |
| title_fullStr | CK2 and the Hallmarks of Cancer |
| title_full_unstemmed | CK2 and the Hallmarks of Cancer |
| title_short | CK2 and the Hallmarks of Cancer |
| title_sort | ck2 and the hallmarks of cancer |
| topic | Casein kinase 2 CK2 cancer hallmarks of cancer |
| url | https://www.mdpi.com/2227-9059/10/8/1987 |
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